Table 2. Comprehensive Receptor Target Profile of Norpsilocin Analoguesa.
| Receptor | Subtype |
|---|---|
| Serotonergic | 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6, 5-HT7A |
| Adrenergic | α1A, α1B, α1D, α2A, α2B, α2C, β1, β2 |
| Dopaminergic | D1, D2, D3, D4, D5 |
| GABAergic | GABAA, PBR, BZP (rat brain site) |
| Glutamatergic | NMDA, NR2B, Kainate (rat brain) |
| Histaminergic | H1, H2, H3, H4 |
| Monoaminergic transporter | DAT, NET, SERT |
| Muscarinic | M1, M2, M3 M4, M5 |
| Nicotinic acetylcholine | α2β2, α2β4, α 3β 2, α3β4, α4β2, α2β2 (rat brain), α7 |
| Opioidergic | δ, μ, κ |
| Sigmaergic | σ1, σ2 |
a
Hits (bolded text) were defined by one or more compounds exhibiting >50% average inhibition at a 10 μM test concentration (a single experiment with quadruplicate determinations) and advanced to full competition binding assays to determine inhibition constants.