Table 1. Radioligand Binding Studies in Brain Homogenatesa.
| SMBT-1 concentration range versus | group | site 1 (superhigh affinity) | site 2 (high affinity) |
|---|---|---|---|
| [3H]-l-deprenyl (10 nM) | |||
| Frontal Cortex | |||
| 10–15–10–5 M | CN | N/A | 34.6 × 10–9 M |
| 10–15–10–5 M | AD | N/A | 53.2 × 10–9 M |
| Temporal Cortex | |||
| 10–15–10–5 M | CN | N/A | 22.6 × 10–9 M |
| 10–15–10–5 M | AD | N/A | 12.3 × 10–9 M |
| [3H]-BU99008 (1 nM) | |||
| Frontal Cortex | |||
| 10–15–10–7 M | CN | 0.20 × 10–12 M | 9.3 × 10–9 M |
| 10–15–10–7 M | AD | 0.20 × 10–12 M | 187 × 10–9 M |
| Temporal Cortex | |||
| 10–15–10–7 M | CN | 0.3 × 10–12 M | 1015 × 10–9 M |
| 10–15–10–7 M | AD | 0.06 × 10–12 M | 22.7 × 10–9 M |
a
AD, Alzheimer’s disease; CN, cognitively normal control; N/A, not applicable/available.