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. 2024 Jan 5;14:1297367. doi: 10.3389/fgene.2023.1297367

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Copyright © 2024 Guerra, Trerotola, Relli, Lattanzio, Boujnah, Travali, Moschella, Todaro, Pierdomenico, Di Pietro, Tinari and Alberti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The NHP Trop-2 protein structure. NHP 3D structures were modeled versus the crystal structure of the human Trop-2 (Pavšič, 2021), following the described procedures (Materials and Methods). The 3D modeling parameters are listed in Supplementary Table S1. Polymorphic residues versus the human Trop-2 sequence are in red. (A) Side (macaca, baboon, orangutan) and frontal (gibbon) views of primate Trop-2s (Supplementary Table S1). The 3D model surface representation was obtained with PyMol (Supplementary Table S1). (B) (i) Side and (ii) frontal views of the marmoset Trop-2 3D structure. (iii) Overlap of the human and marmoset Trop-2 is in ribbon/contour diagrams. Alpha helices, beta sheets (flat arrows) and loops are shown. The ribbon diagram of marmoset Trop-2 is in blue; that of the human Trop-2 is in cyan. (blue arrows) Phe94 in marmoset versus Leu97 in human and Lys194 in marmoset versus Glu197 in human are magnified.