Table 3.
Association between GKN1 polymorphism rs4254535 in allele model and prognosis in Chinese patients with lung cancer.
| Variables | Death/survive | HR (95% CI) | P | HR* (95% CI) | P* | |
|---|---|---|---|---|---|---|
| T (ref) | C | |||||
| Sex | ||||||
| Female | 243/89 | 89/37 | 0.84 (0.66-1.07) | 0.159 | 0.82 (0.65-1.05) | 0.118 |
| Male | 718/157 | 280/59 | 0.93 (0.81-1.07) | 0.306 | 0.93 (0.81-1.07) | 0.322 |
| Age | ||||||
| Age < 60 | 339/122 | 121/46 | 0.91 (0.74-1.12) | 0.358 | 0.86 (0.69-1.06) | 0.146 |
| Age >= 60 | 622/124 | 248/50 | 0.91 (0.78-1.05) | 0.195 | 0.91 (0.78-1.06) | 0.214 |
| Smoking status | ||||||
| Nonsmoker | 247/96 | 91/40 | 0.82 (0.64-1.04) | 0.097 | 0.81 (0.64-1.04) | 0.096 |
| Smoker | 694/139 | 274/51 | 0.94 (0.82-1.08) | 0.408 | 0.95 (0.82-1.09) | 0.372 |
| Family History | ||||||
| Yes | 336/80 | 152/30 | 1.04 (0.86-1.26) | 0.690 | 1.03 (0.85-1.25) | 0.775 |
| No | 625/166 | 217/66 | 0.82 (0.71-0.96) | 0.014 | 0.84 (0.72-0.98) | 0.028 |
| Stage | ||||||
| Early stage | 117/107 | 35/49 | 0.79 (0.54-1.15) | 0.216 | 0.79 (0.54-1.16) | 0.234 |
| Late stage | 771/131 | 303/39 | 0.91 (0.80-1.04) | 0.160 | 0.90 (0.79-1.03) | 0.135 |
| Subtype | ||||||
| ADC | 407/123 | 143/59 | 0.77 (0.63-0.93) | 0.006 | 0.77 (0.64-0.94) | 0.008 |
| SCC | 331/65 | 145/21 | 1.06 (0.87-1.29) | 0.545 | 1.06 (0.87-1.28) | 0.587 |
| SCLC | 86/20 | 30/6 | 0.75 (0.49-1.15) | 0.188 | 0.73 (0.47-1.13) | 0.156 |
| NSCLC | 875/226 | 339/90 | 0.92 (0.81-1.04) | 0.190 | 0.92 (0.81-1.04) | 0.198 |
* Adjusted by age, gender. CI, confidence interval; HR, hazard ratio; ref, reference.