Table 5.
Association between GKN1 polymorphism rs4254535 in dominant genotype and prognosis of Chinese patients with lung cancer.
| Variables | Death/survive | HR (95% CI) | P | HR* (95% CI) | P* | |
|---|---|---|---|---|---|---|
| T/T (ref) | T/C + C/C | |||||
| Sex | ||||||
| Female | 92/37 | 74/26 | 0.95 (0.70-1.29) | 0.731 | 0.93 (0.68-1.27) | 0.647 |
| Male | 254/56 | 245/52 | 0.91 (0.76-1.09) | 0.297 | 0.91 (0.77-1.09) | 0.314 |
| Age | ||||||
| Age < 60 | 126/47 | 104/37 | 0.93 (0.72-1.21) | 0.587 | 0.92 (0.71-1.20) | 0.545 |
| Age >= 60 | 220/46 | 215/41 | 0.93 (0.77-1.12) | 0.450 | 0.94 (0.77-1.13) | 0.487 |
| Smoking stage | ||||||
| Nonsmoker | 93/39 | 76/29 | - | - | - | - |
| Smoker | 245/51 | 239/44 | 0.95 (0.79-1.13) | 0.536 | 0.95 (0.79-1.14) | 0.569 |
| Family History | ||||||
| Yes | 116/30 | 128/25 | 1.14 (0.89-1.47) | 0.295 | 1.14 (0.88-1.47) | 0.325 |
| No | 230/63 | 191/53 | 0.81 (0.67-0.99) | 0.036 | 0.82 (0.68-1.00) | 0.046 |
| Stage | ||||||
| Early stage | 45/34 | 31/44 | 0.68 (0.43-1.08) | 0.102 | 0.68 (0.43-1.08) | 0.100 |
| Late stage | 275/57 | 262/28 | 0.99 (0.84-1.18) | 0.931 | 0.98 (0.83-1.16) | 0.817 |
| Subtype | ||||||
| ADC | 151/44 | 124/47 | 0.78 (0.61-0.98) | 0.037 | 0.78 (0.61-0.99) | 0.039 |
| SCC | 110/25 | 128/18 | 1.07 (0.83-1.38) | 0.598 | 1.05 (0.81-1.36) | 0.694 |
| SCLC | 32/9 | 26/4 | 0.89 (0.53-1.51) | 0.671 | 0.86 (0.50-1.46) | 0.574 |
| NSCLC | 314/84 | 293/74 | 0.93 (0.80-1.09) | 0.393 | 0.93 (0.79-1.09) | 0.339 |
* Adjusted by age, gender. CI, confidence interval; HR, hazard ratio; ref, reference.