Skip to main content
. 2024 Jan 1;20(3):848–863. doi: 10.7150/ijbs.91154

Figure 6.

Figure 6

DLBCL-derived exosomal ENO2 regulated macrophages glycolysis via GSK3β/β-catenin/c-Myc signaling pathway. A-B. The protein expression levels of p-GSK3β (Ser9), β-catenin and c-Myc were detected in THP-1 macrophages stimulated by exosomes from different ENO2 stably transfected DLBCL cells; ICG001 can decrease the protein expression levels of β-catenin and c-Myc in THP-1 macrophages; SKL2001 can increase the protein expression levels of β-catenin and c-Myc in THP-1 macrophages. THP-1 macrophages were treated with ICG001 or SKL2001 for 1 h and then stimulated by exosomes from DLBCL cells for 24 h. Glycolysis-related indicators were detected. C. Glucose consumption of THP-1 macrophages. D. ATP production of THP-1 macrophages. E. Lactate production of THP-1 macrophages. F-G. ECAR of THP-1 macrophages. Data were shown as the mean±SD. *p<0.05, **p<0.01, ***p<0.001.