Figure 8.

The diagrammatic representation depicted the positive feedback loop between DLBCL cells and TAMs. DLBCL-derived exosomes can be absorbed by THP-1 macrophages. DLBCL-derived exosomal ENO2 can up-regulate the phosphorylation of GSK3β (Ser9) of macrophages, and then promoted the expression and nuclear translocation of β-catenin, which can accelerate glycolysis (Glucose consumption, ATP production, Lactate production, ECAR ) by activating c-Myc. These processes promoted macrophages to an M2-like phenotype (increased M2 macrophages markers and decreased M1 macrophages markers), which in turn promoted the proliferation, migration and invasion of DLBCL cells. DLBCL, Diffuse large B-cell lymphoma; TME, Tumor microenvironment; TAMs, Tumour-associated macrophages; ECAR, Extracellular acidification rate.