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. 2024 Jan 4;14:1303430. doi: 10.3389/fpsyt.2023.1303430

Table 2.

Cross-trait meta-analysis results between educational attainment and neuropsychiatric traits (PCPASSOC < 3.8 × 10−9 and Psingle-trait < 1 × 10−5).

Trait Index SNP POS EA NEA Trait 1 Trait 2 P CPASSOC Genes
BETA P BETA P
ADHD rs673253 chr1p34.2 T C 0.015 8.28E-10 −0.092 1.53E-11 1.17E-14 [KDM4A, PTPRF]
rs3791101 chr1p34.1 A G 0.012 7.14E-06 −0.097 5.3E-11 7.98E-11 [MIR6079, ST3GAL3]
rs549845 chr1p34.2 A G 0.015 5.78E-08 −0.093 1.38E-10 1.832E-10 [KDM4A, PTPRF, ST3GAL3]
rs62260755 chr3p21.31 C G 0.021 3.37E-12 −0.080 6.74E-07 1.026E-12 [CAMKV, TRAIP, CDHR4, MST1R, UBA7]
rs304137 chr5q14.3 A G −0.016 1.78E-10 0.064 1.79E-06 3.228E-16 [MEF2C]
rs12653396 chr5q14.3 A T −0.013 2.14E-07 0.073 1.13E-07 3.725E-11 [LINC00461]
rs4839923 chr6q16.1 A G −0.013 1.1E-07 0.065 1.9E-06 4.286E-11 [MIR2113]
AN rs13093385 chr3p21.31 A T −0.028 3.43E-22 −0.071 1E-06 4.377E-25 [APEH, BSN, MST1, RNF123]
rs13096760 chr3p21.31 T C 0.015 5.18E-09 0.065 1.45E-06 2.463E-17 [APEH, BSN, MST1, RNF123]
rs9821797 chr3p21.31 A T 0.02 2.4E-07 −0.157 6.99E-15 7.55E-15 [IP6K2, NCKIPSD, MIR4793]
rs73073015 chr3p21.31 A G 0.023 9.32E-08 −0.173 3.24E-13 3.887E-13 [DAG1, NICN1, AMT, RHOA, GPX1]
rs9832454 chr3p21.31 T C 0.023 2.27E-07 −0.125 1.68E-07 1.428E-11 [GNAI2, GNAT1, MIR566,
SEMA3F, RBM5, RBM6]
rs6967776 chr7q33 A G −0.016 1.54E-07 −0.075 9.43E-06 7.207E-10 [EXOC4]
rs705696 chr12q13.2 A G 0.018 2.5E-11 −0.064 7.67E-06 9.125E-12 [ERBB3]
ASD rs9320913 chr6q16.1 A C 0.024 2.05E-21 0.067 1.51E-06 1.196E-36 [MIR2113]
rs1106761 chr8q24.3 A G −0.017 4.08E-11 −0.065 7.16E-06 1.514E-09 [MROH5]
rs62057121 chr17q21.31 A G −0.018 2.8E-08 0.078 5.94E-06 1.066E-11 [CRHR1, KANSL1-AS1, MAPT,
MAPT-AS1, SPPL2C, STH]
AUD rs2101975 chr4q24 A G 0.013 2.75E-07 −0.006 5.5E-06 1.655E-14 [TET2, PPA2]
rs1338549 chr6q16.1 T G 0.021 8.26E-17 −0.005 6.73E-06 1.4E-30 [MIR2113]
rs13266268 chr8q24.3 T C −0.017 4.1E-11 −0.006 3.95E-06 6.634E-12 [MROH5]
rs113925422 chr17q21.31 A T −0.018 1.02E-07 −0.008 2.6E-08 3.904E-14 [MAPT, MAPT-AS1, SPPL2C, STH]
rs538628 chr17q21.31 C G −0.018 2.16E-08 −0.008 3.27E-08 4.408E-14 [NSF, WNT3]
rs1879581 chr17q21.31 T C 0.016 2.1E-06 −0.007 5.16E-06 5.599E-11 [PLEKHM1]
BIP rs12754946 chr1p31.1 T C 0.012 1.77E-06 0.066 2.39E-06 1.19E-10 [AK5]
rs9320913 chr6q16.1 A C 0.024 2.05E-21 0.070 1.27E-07 5.566E-37 [MIR2113]
rs10429537 chr9p21.3 C G −0.025 1.02E-21 −0.067 1.21E-06 6.978E-19 [ELAVL2]
CUD rs12122664 chr1p22.2 A C 0.013 6.22E-07 −0.083 1.92E-06 2.768E-09 [BARHL2]
rs11711407 chr3p21.31 A G −0.020 3.73E-15 0.077 6.41E-06 2.34E-23 [GNAT1, SEMA3F, SLC38A3]
rs35926495 chr3p21.31 T C −0.017 1.31E-11 0.088 2.73E-07 1.608E-12 [GNAT1, GNAI2, LSMEM2, MIR566,
NAT6, SEMA3B, SLC38A3]
rs9467773 chr6p22.2 A G 0.012 3E-06 −0.074 9.13E-06 1.868E-11 [BTN1A1, HCG11]
rs7783012 chr7q31.1 A G −0.013 4.69E-07 0.101 1.84E-09 4.17E-12 [FOXP2]
MDD rs7531118 chr1p31.1 T C −0.012 1.84E-06 −0.045 2.15E-08 4.392E-10 [RPL31P12]
rs76025409 chr5q21.2 C G −0.012 5.14E-06 0.057 2.32E-11 5.972E-11 [RP11-6 N13.1]
PTSD rs71351952 chr20q13.13 T C 0.013 9.6E-06 0.078 4.94E-06 1.772E-09 [ARFGEF2, CSE1L,
LOC102723483, STAU1]
TS rs9401593 chr6q16.1 A C −0.024 1.71E-21 0.128 7.87E-07 4.122E-35 [MIR2113]
rs12154193 chr6q16.1 C G −0.017 1.38E-11 0.116 9.62E-06 3.961E-18 [MIR2113]
rs1619561 chr12q24.31 C G −0.023 1.44E-14 0.144 5.06E-06 6.059E-15 [MPHOSPH9]

EA, Effect allele; NEA, non-effect allele; Trait 1 refers to the EA trait; Trait 2 refers to the corresponding neuropsychiatric traits. PCPASSOC means the cross-trait meta-analysis p value. EA, educational attainment.; ADHD, Attention deficit/hyperactivity disorder; AN, Anorexia nervosa; ASD, Autism spectrum disorders; AUD, Alcohol use disorders; BIP, Bipolar disorder; CUD, Cannabis use disorder; MDD, Major depressive disorder; PTSD, Posttraumatic stress disorder; TS, Tourette’s syndrome.