Table 1.
Typical functionality (during selective activation) of glutamate and GABA receptors.
| Receptor | Subtype | Typical functionality (during selective activation) |
|---|---|---|
| NMDA | NR1 | Glycine-dependent receptor deactivation Localizes with NR2 |
| NMDA | NR2A | Enhancement of excitatory synapses Localizes with NR1 Responds and initiates LTP |
| NMDA | NR2B | Ca2+ influx mediation Prolongs Ca2+ influx Responds and initiates LTD |
| AMPA | GluR1 | Upregulated density in LTP Phosphorylates in LTP Permits Na+ and Ca2+ permeability |
| AMPA | GluR2 | Restricts Ca2+ permeability |
| GABA | A-δ | Inhibition of potentiated response Responds to changes in GABA concentrations |
LTP, long-term potentiation; Ca2+, calcium; LTD, long-term depression; Na+, sodium.