Table 2.
Evaluating Biomarkers in Identifying CAD Severity
| Biomarker | Comparisons of different CAD severities | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| MI VS Control | UA VS Control | SACD VS Control | |||||||
| AUC | P value | 95% CI | AUC | P value | 95% CI | AUC | P value | 95% CI | |
| Gut bacterial species | |||||||||
| Faecalibacterium_prausnitzii | 0.728 | < 0.001 | 0.647–0.81 | 0.717 | < 0.001 | 0.645–0.79 | 0.78 | < 0.001 | 0.703–0.856 |
| Dorea_longicatena | 0.659 | 0.002 | 0.565–0.753 | 0.746 | < 0.001 | 0.659–0.833 | |||
| Eubacterium_ramulus | 0.654 | 0.003 | 0.556–0.753 | ||||||
| Lachnospiraceae_bacterium_1_1_57FAA | 0.664 | 0.001 | 0.575–0.752 | ||||||
| Lactobacillus_mucosae | 0.646 | 0.004 | 0.544–0.747 | ||||||
| Megasphaera_micronuciformis | 0.607 | 0.036 | 0.502–0.712 | ||||||
| Eubacterium_hallii | 0.646 | 0.001 | 0.564–0.728 | ||||||
| Roseburia_hominis | 0.669 | < 0.001 | 0.59–0.748 | ||||||
| Anaerostipes_hadrus | 0.633 | 0.002 | 0.55–0.716 | 0.681 | 0.001 | 0.581–0.78 | |||
| Ruminococcus_obeum | 0.648 | 0.001 | 0.5690.728 | 0.716 | < 0.001 | 0.626–0.806 | |||
| Ruminococcus_sp_51_39BFAA | 0.669 | < 0.001 | 0.588–0.75 | 0.751 | < 0.001 | 0.659–0.844 | |||
| Bacteroides_ovatus | 0.731 | < 0.001 | 0.637–0.824 | ||||||
| Dorea_formicigenerans | 0.628 | 0.017 | 0.527–0.728 | ||||||
| Ruminococcus_bromii | 0.698 | < 0.001 | 0.603–0.792 | ||||||
| Ruminococcus_torques | 0.699 | < 0.001 | 0.594–0.804 | ||||||
| Fecal metabolites | |||||||||
| Cyclohexylsulfamate | 0.763 | 0.025 | 0.512–1 | ||||||
| 1-Palmitoylglycerol | 0.831 | 0.005 | 0.677–0.986 | ||||||
| Phe-Ile | 0.763 | 0.025 | 0.56–0.966 | ||||||
| 2-Dehydro-3-deoxy-D-gluconate | 0.712 | 0.013 | 0.549–0.875 | ||||||
| Ile-Thr | 0.688 | 0.028 | 0.511–0.865 | ||||||