Table 3:

Clinical trial of oral versus intravenous antibiotic treatment in people who inject drugs with infective endocarditis (IE)

Reference	Patients, no. (%)		IE patients no. (%)	Microbiology	Mortality			Cure†			Toxicity‡
	IV	PO			IV	PO	p-value	IV	PO	p-value	IV	PO	p-value
Heldman et al, 1996 (10)	45 (52.9)	40 (47.1)	85 (100)	93.5% S. aureus	2.1%	0%	NR*	91%	90%	0.9	61.5%	2.8%	<0.001

^* Not reported

^† Defined as sterile blood cultures days 6 and 7, and 34 and 35 after cessation of antibiotics

^‡ Defined as hepatotoxicity (rise in serum transaminases from normal to <150 IU L⁻¹ or from an abnormal baseline to a threefold increase associated with at least 7 days of study drug treatment) or nephrotoxicity (50% reduction in calculated creatinine clearance using Cockcroft and Gault formula)