Table 4.

Statistics for proteins with strong colocalization support (regional colocalization probability, RCP > 0.9) from all 35 proteins with nominally significant (p < 0.05) association in the MR analysis

Entrez gene symbol	SNP	RCP (FEV1 × AGES-Reykjavik)	FEV1 GWAS P-value [β]	AGES-Reykjavik protein association p-value [β]	deCODE protein association p-value [β]
THBS2	rs32531	0.9976	1.3 × 10–10 [0.02]	1.4 × 10–19 [− 0.18]	2.1 × 10–186 [− 0.26]
THBS2	rs77567421	0.9775	6.3 × 10–10 [0.02]	2.8 × 10–19 [− 0.19]	–3
THBS2	rs77718381	0.9710	7.0 × 10–10 [0.02]	1.8 × 10–19 [− 0.19]	–3
TNFSF12	rs49682002	0.9995	4.5 × 10–11 [0.02]	5.6 × 10–113 [0.63]	–3

For each protein, all variants with RCP > 0.9 are shown, together with their P-values and beta estimates for associations with FEV1 in a recent GWAS [29] and protein levels in the AGES-Reykjavik [24] and deCODE [32] studies

SNP: Single nucleotide polymorphism, RCP: Regional Colocalization Probability, AGES: Age/Gene Environment Susceptibility, GWAS: Genome-Wide Association Study, THBS2: Thrombospondin-2, TNFSF12: Tumor necrosis factor ligand superfamily member 12, FEV1: Forced Expiratory Volume in 1 s

¹Lead variant in FEV1 GWAS is rs3253

²Lead variant in FEV1 GWAS is rs4968200

³Variant data was not available in deCODE summary statistics