TABLE 2.
Association between ECW/TBW status and patient survival outcome.
| Clinicopathological factors | Univariate HR (95% CI) | p value | Multivariate HR (95% CI) a | p value |
|---|---|---|---|---|
| Relapse free survival | ||||
| Sex | ||||
| Male/Female | 0.71 (0.41–1.22) | 0.208 | 0.95 (0.54–1.67) | 0.858 |
| Age | ||||
| ≥ 65/ < 65 | 2.09 (1.15–4.07) | 0.015 | 1.69 (0.85–3.35) | 0.131 |
| BMI | ||||
| <18.5/18.5≤, <25 | 1.32 (0.50–2.92) | 0.547 | 0.70 (0.27–1.80) | 0.463 |
| ≥25/18.5≤, <25 | 1.03 (0.52–1.91) | 0.923 | 1.42 (0.73–2.73) | 0.298 |
| Tumor location | ||||
| Right side/Left side | 1.10 (0.58–1.95) | 0.763 | 0.95 (0.50–1.83) | 0.885 |
| Depth of tumor invasion | ||||
| T3–T4/T1–T2 | 2.69 (1.48–5.24) | <0.001 | 2.05 (1.06–3.96) | 0.032 |
| Lymph node metastasis | ||||
| Positive/Negative | 2.88 (1.68–4.97) | <0.001 | 2.77 (1.33–5.76) | 0.006 |
| Postoperative complication | ||||
| CD classification ≥III/ <III | 1.89 (0.95–3.49) | 0.070 | 1.85 (0.91–3.77) | 0.090 |
| Preoperative chemotherapy | ||||
| Presence/Absence | 0.40 (0.06–2.91) | 0.367 | 0.33 (0.04–2.44) | 0.277 |
| Adjuvant chemotherapy | ||||
| Presence/Absence | 1.70 (0.96–2.93) | 0.069 | 0.84 (0.39–1.81) | 0.650 |
| ECW/TBW | ||||
| High/Low | 2.52 (1.43–4.67) | 0.001 | 2.07 (1.10–3.88) | 0.024 |
| Overall survival | ||||
| Sex | ||||
| Male/Female | 1.22 (0.57–2.84) | 0.621 | 1.97 (0.83–4.66) | 0.122 |
| Age | ||||
| ≥65/<65 | 3.94 (1.51–13.48) | 0.004 | 2.73 (0.90–8.27) | 0.075 |
| BMI | ||||
| <18.5/18.5≤, <25 | 1.52 (0.35–4.61) | 0.530 | 0.78 (0.21–2.95) | 0.714 |
| ≥25/18.5≤, <25 | 1.53 (0.64–3.44) | 0.325 | 1.98 (0.82–4.76) | 0.128 |
| Tumor location | ||||
| Right side/Left side | 2.40 (1.10–5.15) | 0.029 | 2.03 (0.89–4.61) | 0.093 |
| Depth of tumor invasion | ||||
| T3–T4/T1–T2 | 1.48 (0.69–3.37) | 0.315 | 1.42 (0.61–3.27) | 0.415 |
| Lymph node metastasis | ||||
| Positive/Negative | 1.35 (0.58–2.94) | 0.468 | 1.64 (0.55–4.87) | 0.373 |
| Postoperative complication | ||||
| CD classification ≥III/<III | 1.08 (0.32–2.82) | 0.890 | 1.39 (0.45–4.32) | 0.566 |
| Preoperative chemotherapy | ||||
| Presence/Absence | – | 0.999 | – | 0.999 |
| Adjuvant chemotherapy | ||||
| Presence/Absence | 1.04 (0.43–2.30) | 0.924 | 0.67 (0.21–2.14) | 0.502 |
| ECW/TBW | ||||
| High/Low | 3.70 (1.58–10.13) | 0.002 | 3.23 (1.25–8.36) | 0.016 |
Abbreviations: CD classification, Clavien–Dindo classification; CI, confidence interval; ECW, extracellular water; HR, hazard ratio; TBW, total body water.
a
Multivariate Cox proportional hazards regression model was adjusted for sex, age, tumor location, depth of tumor invasion, lymph node metastasis, postoperative complication and ECW/TBW status.