Table 2.

TDSEV-derived components as prospective biomarkers for the diagnosis and prognosis of different types of cancer

S. No	Types of cancer	SEV components	Diagnostic/Prognostic significance	References
1	Breast cancer	miR-223-3p	Biomarker for early detection of breast metastasis	[258]
2	Breast cancer	miR-222	It is connected to lymphatic metastasis in highly expressed breast cancer	[241]
3	Lung cancer	miR-106b	It is extensively expressed in serum and has been linked to lymph node metastasis as well as MMP protein expiration in lung cancer metastasis	[259]
4	Lung cancer	miR-451a	It aids in the spread of lung cancer to lymph nodes	[240]
5	Colon cancer	CD147	It is substantially expressed in patients with colon cancer	[260]
6	Colon cancer	miR-203	It is significantly expressed in colon cancer and is linked to liver metastasis	[261]
7	Prostate cancer	miR-501-3p	It is reduced in prostate tumors, yet it lowers E-cadherin expression and boosts metastasis	[262]
8	Prostate cancer	miR-1290 and miR-375	These are significantly expressed in prostate cancer and are linked to poor overall survival in castration-resistant patients	[263]
9	Liver cancer	circRNA- 100,338	It promotes the metastasis of liver cancer	[264]
10	Liver cancer	miR-126	It is a useful prognostic biomarker for liver cancer	[265]