Table 5.

Sex-specific alterations in gut microbiota related to CHD

Men vs women with CHD RF model	CHD patients vs non-CVD individuals in RF models for men and women separately
g_UBA1819 (Ruminococcaceae)	Bacterial taxa identified by RF to distinguishing CHD women from non-CVD women
g_Bilophila	Bacterial taxa identified by RF to distinguishing CHD women from non-CVD women
g_Phascolarctobacterium	Bacterial taxa identified by RF to distinguishing CHD women from non-CVD women
f_Barnesiellaceae	Bacterial taxa identified by RF to distinguishing CHD men from non-CVD men
g_Subdoligranulum	Bacterial taxa identified by RF to distinguishing CHD men from non-CVD men
Ruminococcaceae incertae sedis	Bacterial taxa identified by RF to distinguishing CHD women from non-CVD women

The sex-specific alterations in gut microbiota related to CHD were selected according to the following criteria: (1) bacterial taxa critical to distinguishing CHD men from non-CVD men or bacterial taxa critical to distinguishing CHD women from non-CVD women (CHD patients vs non-CVD individuals in models for men and women separately). (2) Bacterial taxa that significantly differentiated CHD men and CHD women (men vs women with CHD model column). CHD coronary heart disease, CVD cardiovascular disease, RF random forest