Table 3.

Comparisons of biomarkers according to severity (CCDC scale and WHO OS)

	Severe and critical	Moderate	p-value
CCDC scale
Neutrophils/mm3	6700 [4575; 10725]	4600 [3500; 6400]	< 0.001
IL-8 (pg/mL)	58.22 [46.90; 97.08]	49.89 [35.59; 80.94]	0.015
G-CSF (pg/mL)	148.16 [126.10; 163.97]	142.01 [122.64; 156.55]	0.162
MPO-DNA	0.84 [0.64; 1.03]	0.78 [0.63; 0.99]	0.563
NE-DNA	0.98 [0.86; 1.29]	1.06 [0.91; 1.24]	0.394
cfDNA (ng/mL)	9.44 [6.15; 20.19]	6.21 [3.46; 10.44]	< 0.001
CitH3 (ng/mL)	28.28 [16.19; 57.92]	28.43 [17.93; 51.13]	0.670
WHO OS
Neutrophils/mm3	6600 [4500; 10775]	4600 [3550; 6350]	< 0.001
IL-8 (pg/mL)	58.80 [46.72; 102.29]	49.15 [36.85; 72.20]	0.007
G-CSF (pg/mL)	150.75 [131.66; 168.10]	136.76 [120.48; 153.66]	0.002
MPO-DNA	0.80 [0.64; 1.02]	0.80 [0.64; 1.00]	0.873
NE-DNA	1.04 [0.87; 1.31]	1.05 [0.89; 1.24]	0.945
cfDNA (ng/mL)	9.08 [5.54; 19.38]	6.88 [3.61; 10.73]	0.001
CitH3 (ng/mL)	31.79 [15.08; 57.53]	26.80 [18.37; 49.48]	0.388

	Critical	Moderate and severe	p-value
CCDC scale
Neutrophils/mm3	8250 [5400; 12100]	4900 [3700; 6600]	< 0.001
IL-8 (pg/mL)	68.60 [47.40; 94.41]	52.57 [37.56; 82.75]	0.058
G-CSF (pg/mL)	152.80 [131.66; 177.42]	140.17 [122.64; 156.55]	0.009
MPO-DNA	0.84 [0.68; 1.01]	0.78 [0.63; 1.01]	0.470
NE-DNA	0.99 [0.86; 1.35]	1.05 [0.89; 1.24]	0.669
cfDNA (ng/mL)	14.11 [7.13; 22.67]	7.01 [4.01; 10.93]	< 0.001
CitH3 (ng/mL)	27.67 [12.88; 53.68]	30.58 [19.08; 54.70]	0.324