Table 2.
Associations between inflammatory markers and infertility
| Inflammatory markers | Total, n | Infertility, n | Crude Model | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | |||
| log2-SII | 3105 | 431 | 0.95 (0.78, 1.15) | 0.60 | 0.91 (0.74, 1.10) | 0.32 | 0.82 (0.66, 1.02) | 0.07 | 0.82 (0.66, 1.02) | 0.08 |
| Q1 [5.40, 8.45] | 778 | 117 | ref | ref | ref | ref | ||||
| Q2 (8.45, 8.93] | 774 | 106 | 0.87 (0.61, 1.25) | 0.45 | 0.81 (0.57, 1.17) | 0.26 | 0.77 (0.53, 1.11) | 0.16 | 0.77 (0.52, 1.12) | 0.17 |
| Q3 (8.93, 9.38] | 776 | 92 | 0.71 (0.49, 1.03) | 0.07 | 0.65 (0.44, 0.95) | 0.03 | 0.57 (0.38, 0.85) | 0.01 | 0.56 (0.37, 0.85) | 0.01 |
| Q4 (9.38, 12.51] | 777 | 116 | 1.08 (0.76, 1.53) | 0.65 | 0.97 (0.68, 1.38) | 0.87 | 0.83 (0.55, 1.25) | 0.37 | 0.83 (0.55, 1.27) | 0.38 |
| log2-LC | 3105 | 431 | 1.42 (1.00, 2.00) | 0.05 | 1.51 (1.06, 2.16) | 0.02 | 1.33 (0.93, 1.90) | 0.12 | 1.33 (0.93, 1.92) | 0.12 |
| Q1 [-1.00, 0.93] | 959 | 124 | Ref | Ref | Ref | Ref | ||||
| Q2 (0.93, 1.20] | 768 | 86 | 0.77 (0.53, 1.11) | 0.16 | 0.79 (0.55, 1.12) | 0.17 | 0.72 (0.51, 1.03) | 0.07 | 0.72 (0.51, 1.03) | 0.07 |
| Q3 (1.20, 1.43] | 603 | 93 | 1.06 (0.75, 1.50) | 0.74 | 1.08 (0.75, 1.57) | 0.67 | 0.97 (0.67, 1.40) | 0.86 | 0.98 (0.68, 1.40) | 0.90 |
| Q4 (1.43, 2.72] | 775 | 128 | 1.46 (1.04, 2.03) | 0.03 | 1.55 (1.11, 2.18) | 0.01 | 1.36 (0.95, 1.94) | 0.09 | 1.35 (0.94, 1.94) | 0.10 |
| log2-PPN | 3105 | 431 | 1.17 (0.94, 1.47) | 0.15 | 1.17 (0.92, 1.47) | 0.19 | 1.01 (0.79, 1.28) | 0.95 | 1.01 (0.79, 1.28) | 0.94 |
| Q1 [8.00, 10.47] | 778 | 95 | Ref | Ref | Ref | Ref | ||||
| Q2 (10.47, 10.89] | 774 | 121 | 1.52 (1.02, 2.26) | 0.04 | 1.57 (1.05, 2.35) | 0.03 | 1.38 (0.92, 2.08) | 0.11 | 1.38 (0.92, 2.07) | 0.11 |
| Q3 (10.89, 11.30] | 777 | 101 | 1.13 (0.77, 1.66) | 0.53 | 1.13 (0.77, 1.66) | 0.52 | 0.96 (0.64, 1.45) | 0.85 | 0.96 (0.63, 1.44) | 0.82 |
| Q4 (11.30, 13.42] | 776 | 114 | 1.50 (1.04, 2.15) | 0.03 | 1.52 (1.03, 2.24) | 0.03 | 1.19 (0.79, 1.79) | 0.39 | 1.20 (0.80, 1.79) | 0.37 |
| log2-PLR | 3105 | 431 | 0.80 (0.60, 1.05) | 0.10 | 0.74 (0.56, 0.98) | 0.04 | 0.76 (0.57, 1.01) | 0.06 | 0.76 (0.57, 1.00) | 0.05 |
| Q1 [3.68, 6.56] | 779 | 123 | Ref | Ref | Ref | Ref | ||||
| Q2 (6.56, 6.85] | 773 | 116 | 0.82 (0.58, 1.14) | 0.23 | 0.82 (0.58, 1.17) | 0.26 | 0.82 (0.57, 1.17) | 0.26 | 0.83 (0.57, 1.19) | 0.30 |
| Q3 (6.85, 7.16] | 777 | 92 | 0.64 (0.45, 0.89) | 0.01 | 0.61 (0.43, 0.87) | 0.01 | 0.60 (0.42, 0.87) | 0.01 | 0.61 (0.43, 0.88) | 0.01 |
| Q4 (7.16, 8.82] | 776 | 100 | 0.82 (0.57, 1.17) | 0.26 | 0.75 (0.52, 1.07) | 0.11 | 0.76 (0.52, 1.11) | 0.15 | 0.75 (0.51, 1.10) | 0.13 |
| log2-NLR | 3105 | 431 | 0.87 (0.58, 1.29) | 0.48 | 0.79 (0.53, 1.19) | 0.26 | 0.73 (0.46, 1.16) | 0.18 | 0.73 (0.46, 1.18) | 0.19 |
| Q1 [0.61, 1.45] | 778 | 115 | Ref | Ref | Ref | Ref | ||||
| Q2 (1.45, 1.69] | 782 | 104 | 0.84 (0.60, 1.18) | 0.30 | 0.78 (0.55, 1.10) | 0.15 | 0.72 (0.51, 1.02) | 0.06 | 0.71 (0.50, 1.02) | 0.06 |
| Q3 (1.69, 1.93] | 772 | 104 | 0.86 (0.59, 1.25) | 0.43 | 0.76 (0.53, 1.11) | 0.15 | 0.72 (0.49, 1.06) | 0.10 | 0.72 (0.49, 1.06) | 0.10 |
| Q4 (1.93, 3.86] | 773 | 108 | 0.98 (0.70, 1.36) | 0.89 | 0.89 (0.64, 1.23) | 0.46 | 0.81 (0.57, 1.16) | 0.24 | 0.81 (0.56, 1.16) | 0.24 |
| log2-LMR | 3105 | 431 | 1.05 (0.78, 1.41) | 0.77 | 1.07 (0.79, 1.45) | 0.64 | 0.99 (0.72, 1.37) | 0.97 | 1.01 (0.73, 1.39) | 0.96 |
| Q1 [0.11, 1.81] | 770 | 96 | Ref | Ref | Ref | Ref | ||||
| Q2 (1.81, 2.12] | 767 | 114 | 1.53 (1.01, 2.30) | 0.04 | 1.48 (0.99, 2.22) | 0.05 | 1.49 (0.99, 2.23) | 0.06 | 1.47 (0.98, 2.20) | 0.06 |
| Q3 (2.12, 2.43] | 827 | 119 | 1.33 (0.87, 2.03) | 0.19 | 1.28 (0.83, 1.98) | 0.26 | 1.18 (0.74, 1.89) | 0.47 | 1.20 (0.75, 1.91) | 0.44 |
| Q4 (2.43, 4.03] | 741 | 102 | 1.14 (0.78, 1.65) | 0.49 | 1.18 (0.81, 1.71) | 0.39 | 1.12 (0.76, 1.63) | 0.56 | 1.12 (0.77, 1.64) | 0.54 |
Crude model was not adjusted. Model 1 was adjusted age(continuous). Model 2 was adjusted for model 1 + BMI (continuous), race (Mexican, Hispanic, White, Black, and Other race), marital status (living alone, and married/living with partner), education (Some college or AA degree above, High school or GED, and Less than 11th grade), smoking status (No, Yes), alcohol user (never, former, mild, and heavy) and PIR (< 1.5, 1.5–3.5, and ≥ 3.5). Model 3 was adjusted for model 2 + PID (No, Yes), and age of menarche (< 15 years or ≥ 15 years). P value in bold indicates statistical significance
Abbreviation: OR odds ratios, CI confidence interval, ref reference group, SII systemic immune inflammation index, LC lymphocyte count, PPN product of platelet and neutrophil count, PLR platelet-lymphocyte ratio, NLR neutrophil–lymphocyte ratio, LMR lymphocyte-monocyte ratio, Q1 the first quartile, Q2 the second quartile, Q3 the third quartile, Q4 the highest quartile