Table 2.

Five most connected domains in the innermost core-layers using their degree k in the full domain networks of S. cerevisiae, C. elegans, D. melanogaster, M. musculus and H. sapiens. Notably, the innermost layer l (equivalent to the innermost core) is not populated by the largest hubs, indicating that a high degree alone does not necessarily imply a central placement in the network. In fact, we observe that with even a considerably low degree k domains are placed in the inner cores, a domain specific feature we call globally central. We also observe highly connected domains that only make it to the outer cores, indicating a locally central position in the respective networks.

S. cerevisiae			C. elegans			D. melanogaster			M. musculus			H. sapiens
domain	l	k	domain	l	k	domain	l	k	domain	l	k	domain	l	k
SH3	4	16	pkinase	6	44	pkinase	6	50	pkinase	8	64	pkinase	8	74
pkinase	4	13	PH	6	38	SH3	6	41	EGF	8	60	EGF	8	64
C2	4	11	SH3	6	33	PH	6	40	PH	8	49	PH	8	59
DAG PE-bind	4	4	efhand	6	27	ank	6	38	SH3	8	49	SH3	8	52
pkinase C	4	4	PDZ	6	26	PDZ	6	35	ig	8	44	ig	8	52
PH	3	14	EGF	5	38	zf-C2H2	5	24	fn31	7	31	zf-C3HC4	7	51
helicase C	3	13	ank	5	36	zf-C3HC4	5	23	Idl-recept a	7	26	WD-40	7	39
zf-C3H4	3	10	zf-C3HC4	5	24	UBA	5	23	tsp 1	7	25	tsp 1	7	27
UBA	3	10	ig	5	24	helicase C	5	22	zf-CCHC	7	24	UBA	7	26
myb DNA-bind	3	10	fn3	5	20	efhand	5	21	WW	7	21	vwc	7	21
WD40	2	11	F-box	4	19	WD-40	4	18	zf-C3HC4	6	48	zf-C2H2	6	31
AAA	2	10	zf-C2H2	4	18	rrm	4	13	WD40	6	31	PHD	6	27
ank	2	8	WD-40	4	17	TPR	4	11	zf-C2H2	6	28	helicase C	6	24
UCH-2	2	6	rrm	4	15	tsp 1	4	10	helicase C	6	22	rrm	6	23
HATPase c	2	6	PHD	4	15	zf-CCHC	4	10	TPR	6	19	TPR	6	23
clathrin	1	3	UBA	3	10	ubiquitin	3	10	PHD	5	25	BRCT	5	18
ENTH	1	2	homeobox	3	10	AAA	3	9	bromodomain	5	19	PWWP	5	14
zf-CCCH	1	2	Kunitz BPTI	3	10	heme 1	3	7	BRCT	5	17	DEAD	5	14
exo-endo-phos	1	2	metallophos	3	9	GTP-EFTU	3	7	SET	5	13	zf-RanBP	5	13
SAP	1	2	Dna J	3	7	kinesin	3	6	DEAD	5	13	myb-DNA bind	5	13