. Author manuscript; available in PMC: 2024 Jan 19.

Published in final edited form as: Compr Physiol. 2023 Jun 26;13(3):4631–4658. doi: 10.1002/cphy.c210046

Table 3.

Studies Investigating Mesenchymal Stem Cell-derived Extracellular Vesicles in Liver Disease

Model of liver disease	Source of MSC EVs	Bioactive cargo	References

TNF-α/Act-D in mice	Mouse bone marrow	Y-RNA-1	(62)
D-Gal-N/LPS in mice	Human menstrual blood	Multiple cytokines	(27)
D-Gal-N/LPS in mice	TNFα-treated human umbilical cord	miR-299-3p	(242)
D-Gal-N/LPS in mice	Adipose tissue	H19	(86)
D-Gal-N/LPS in mice	Adipose tissue	miR-17	(135)
Ischemia reperfusion injury (IRI) in mice	Human bone marrow		(4)
IRI in mice	Mouse bone marrow		(61)
ConA in mice	Mouse bone marrow		(204)
CCl₄ in mice	Human placenta		(21)
2/3 partial hepatectomy + IRI in rats	Rat bone marrow		(33)
CCl₄ in rats	Rat bone marrow		(33)
Chronic CCl₄ in mice	Human umbilical cord blood		(124)
Mdr2^−/− mice	Human bone marrow		(5)
Liver antigens S100	Mouse bone marrow	miR-223	(26)