Table 1. Description of study C-reactive protein assays.
| Test Name (Manufacturer) | Type of Test | Cut-offs or Analytical measuring interval (mg/L) | Sample Type | Time to Result | Previous Studies of Test Performance |
|---|---|---|---|---|---|
| Point-of-care Assays | |||||
| Actim® CRP (Medix Biochemica) | Semi-quantitative, immunochromatographic | <10, 10–40, 40–80, >80 | Whole blood | 5 min | [24, 30, 33] |
| Rapid Response™ CRP Semi-Quantitative Test Strip (Quad Line) (BTNX) | Semi-quantitative, immunochromographic | <10, 10–40, 40–80, >80 | Whole blood, serum, plasma | 5 min | [24]. Per package insert, >99.9% sensitivity and 97.5% specificity for any positive result compared to a leading commercial EIA test. |
| STANDARD™ Q Malaria/CRP Duo (SD Biosensor) | Malaria: qualitative, P.f/Pan Ag* CRP: Semi-quantitative, immunochromographic | >20 | Whole blood | 15 min | No published reports found. Clinical trial in process [34]. |
| Reference Assay | |||||
| Afinion™ CRP (Abbott Laboratories) | Quantitative, solid phase immunochemical | 5–200 (whole blood), 5–160 (serum, plasma) | Whole blood, serum, plasma | 4 min | [24, 30–32, 35] |
*P.f/Pan Ag: Plasmodium falciparum (HRP-2), and Plasmodium sp. (pLDH) antigen