Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 19;10(3):eadg1222. doi: 10.1126/sciadv.adg1222

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 5. — (A) Venn diagram depicting 461 genes differentially up-regulated in iPSC-aCMs from RM and 1103 genes up-regulated in iPSC-aCMs from PC; the iPSC-aCMs were purified from PC via magnetic activated cell sorting before sequencing. (B) Volcano plot showing the distribution of differentially expressed genes in PC compared to RM (red: up-regulated in PC relative to RM, and blue: downregulated in PC relative to RM or up-regulated in RM relative to PC). (C) up-regulated GO pathways in PC related to mature cardiac functions. (D) Up-regulated GO pathways in RM related to fetal and epidermis development. Down-selected genes up-regulated in PC in key cardiac pathways including (E) circulatory system process (GO: 0003013), (F) cell junction organization (GO: 0034330), and (G) actin cytoskeleton organization (GO: 0030036) (n = 3 sequencing replicates).