Fig. 2. Virus-specific stem-like CD8 T cells are maintained up to 8 weeks following initial PD-1 blockade.
(A) LCMV chronically infected mice were treated with αPD-1 every 3 days for 2 weeks. Following treatment cessation, CD8 T cell responses were analyzed at weeks 2, 4, 6, 8, and 10. (B-D) Absolute number of stem-like cells among the LCMV-specific populations indicated above each plot. Data points represent means from 3 pooled experiments ± SEM; n=3-5 mice per group per timepoint; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****; P ≤ 0.0001; ns, non-significant.