TABLE 7.

Effect of considering model 2 regression scores on interpretation of biopsies with no Banff histology rejection (biopsies with BK removed)

Recorded histology and molecular features in 887 biopsies with no rejection by Banff guidelines	Regression diagnoses
	No rejection (N = 827)	TCMR (N = 2)	Mixed (N = 3)	AMR (N = 55)
Histology lesion scores, plus DSA and C4d
TCMR-related
t (tubulitis)	0.11	2.00 c	2.67 c	0.23 a
i (interstitial infiltrate)	0.22	2.00 c	3.00 c	0.73 c
All rejection–related
v (vasculitis)	0.00	0.00	0.00	0.04 c
AMR-related
g (glomerulitis)	0.11	0.00	0.50	1.51 c
ptc (capillaritis)	0.08	0.00	3.00 c	1.04 c
cg (double contours)	0.05	0.00	0.00	1.02 c
Atrophy-fibrosis-related
ci (scarring)	1.06	2.50 a	1.67	1.51 c
ct (atrophy)	1.00	2.50	1.67	1.27
DSA-related
DSA positivity	0.35	0.00	0.00	0.32
C4d-related
C4d positivity	0.06	–	0.50 a	0.14
Transcript set and molecular classifier scores
TCMR-related classifiers
TCMR classifier (TCMRProb)	0.04	0.21 a	0.22 b	0.04 a
All rejection–related
Rejection classifier (RejProb)	0.15	0.33	0.61 a	0.45 c
IFNG-inducible (GRIT3)	0.39	0.87 a	1.18 b	0.65 c
AMR-related
DSA-selective (DSAST)	0.09	0.04	0.20	0.39 c
NK cell burden (NKB)	0.40	0.60	0.83 a	0.87 c
AMRd classifier (ABMRProb)	0.10	0.06	0.08	0.32 c

Wilcoxon test compared with the no-rejection group (significant values are bolded):

^aP < 0.05;

^bP < 0.01;

^cP < 0.001.

^dAMR is used throughout this article per journal style; however, the official classifier name is provided in this table.

AMR, antibody-mediated rejection; BK, polyoma virus; DSA, donor-specific antibody; IFNG, interferon gamma; TCMR, T-cell–mediated rejection.