Figure 3.

Effect of HPV16 E7 gene mutation on cervical carcinogenesis. (A) Volcano plot of differential gene expression. Red indicates up-regulated genes, and blue indicates down-regulated genes. The horizontal dashed line indicates P = .05, and the vertical dashed lines indicate log2FC = +1.5 and log2FC = −1.5; (B) GO enrichment analysis of DEGs. Orange represents BP, green represents CC; (C) KEGG pathway enrichment analysis of DEGs. The abscissa represents the count of enriched genes, and the ordinate represents pathways. The color gradient from blue to red indicates change in P value from small to large after correction. BP = Biological process, CC = cellular component, DEGs = differentially expressed genes, GO = gene ontology, KEGG = Kyoto Encyclopedia of Genes and Genomes.