Table 3.
The summary of meta-analysis of clinicopathological parameters associated with cyclin B1, and B2 expression.
| Target molecule | Clinicopathological parameter | Number of studies | Odds ratio | OR in favor of | Confidence interval | P value of OR | I 2 | P value of I2 |
|---|---|---|---|---|---|---|---|---|
| Cyclin B1 | Age | 2 | 0.61 | Younger age | 0.31–1.19 | .15 | 0 % | .83 |
| Tumor stage | 2 | 0.78 | Lower stage | 0.29–2.12 | .63 | 38 % | .2 | |
| Tumor grade | 4 | 1.29 | Higher grade | 0.42–3.97 | .66 | 67 % | .03 | |
| Histologic type | 2 | 0.68 | Other types | 0.24–1.91 | .47 | 0 % | .67 | |
| Estrogen receptor | 2 | 1.12 | ER positive | 0.51–2.43 | .78 | 2 % | .31 | |
| Cyclin B2 | Age | 2 | 0.64 | Younger age | 0.34–1.2 | .16 | 0 % | .59 |
| Tumor size | 2 | 1.81 | Larger size | 0.74–4.45 | .19 | 30 % | .23 | |
| Tumor grade | 2 | 0.74 | Lower grade | 0.39–1.41 | .36 | 7 % | .3 | |
| Node status | 2 | 0.71 | Node negative | 0.38–1.33 | .29 | 0 % | .63 | |
| Cyclin B1 and B2 | Age | 4 | 0.62 | Younger age | 0.39–0.99 | .04 | 0 % | .95 |
| Tumor grade | 6 | 1.02 | Tumor grade | 0.55–1.89 | .95 | 56 % | .05 |
OR: odds ratio.