Figure 1.

Out-of-sample variance in height, schizophrenia, and educational attainment captured by polygenic scores (R²) created by genome-wide association studies (GWASs) of progressively increasing sample size. R² values for height were obtained from Yengo et al. (2018), for educational attainment from Harden & Koellinger (2020), and for schizophrenia from Ripke et al. (2014). Note that the R² values are from studies that draw from different samples and are not methodologically identical (e.g., polygenic scores of schizophrenia have differing ratios of cases to controls and are calculated as Nagelkerke R²).