Table 5.
Concentrations of the selected parameters associated with glucose metabolism in terms of rs1800795 (IL6).
| Parameter | Control group (N = 50) | Obese group (N = 45) | Diabetic group (N = 23) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| G/G (N = 18) | G/C (N = 18) | C/C (N = 14) | G/G (N = 15) | G/C (N = 23) | C/C (N = 7) | G/G (N = 3) | G/C (N = 9) | C/C (N = 11) | |
| Insulin (mU/L) | 6.40; 7.90; 9.00 | 4.20; 6.30; 8.20 | 4.50; 5.20; 6.90 | 7.90; 13.60; 14.80∗ | 9.65; 14.55; 17.75∗∗∗ | 7.40; 10.25; 19.30 | 4.09; 13.92; 41.70 | 10.65; 17.39; 23.17∗∗∗ | 8.13; 9.91; 20.45$$ |
| Glucagon (pg/mL) | 59.27; 88.35; 125.93 | 58.41; 86.54; 97.54 | 39.20; 74.36; 131.80 | 44.35; 103.36; 112.20 | 46.22; 67.35; 106.85 | — | 82.88; 170.00; 299.41 | 130.80; 173.18; 195.75 | 140.13; 181.69; 221.05 |
| IL-6 (pg/mL) | 8.85; 12.02; 23.68 | 6.07; 8.90; 76.92 | 7.46; 9.91; 20.31 | 6.10; 6.40; 8.78∗ | 6.22; 6.87; 13.52 | 7.06; 8.74; 9.90 | 6.24; 7.17; 7.18 | 5.84; 6.01; 8.94 | 5.92; 6.08; 6.29$$,$$$ |
| Glucose (mmol/L) | 4.56; 4.72; 4.83 | 4.44; 4.81; 5.00 | 4.44; 4.72; 5.06 | 4.72; 5.17; 5.50 | 4.92; 5.17; 5.53 | 5.03; 5.36; 6.25 | 6.04; 9.20; 11.10∗ | 6.60; 6.80; 9.50∗∗∗,$ | 6.30; 8.25; 8.50$$ |
| CRP (mg/L) | 0.20; 0.47; 0.80 | 0.37; 0.89; 1.15 | 0.32; 0.61; 0.91 | 1.11; 1.22; 1.48∗ | 0.97; 1.34; 3.19∗∗∗ | 1.80; 4.52; 6.93$$ | 0.62; 1.33; 14.24 | 1.38; 2.79; 5.41∗∗∗ | 0.69; 1.04; 2.25 |
| Cu (μg/L) | 960.21; 1012.89; 1257.32 | 853.30; 988.99; 1055.65 | 912.33; 994.74; 1059.29 | 889.84; 1001.59; 1114.89 | 991.47; 1075.33; 1167.87 | 974.55; 1148.39; 1321.91 | 1011.00; 1206.00; 1490.00 | 1121.00; 1248.00; 1325.00∗∗∗ | 1016.00; 1082.00; 1221.00$$ |
| Zn (μg/L) | 940.35 ± 130.09 | 969.25 ± 126.96 | 987.86 ± 151.71 | 943.94 ± 118.78 | 985.36 ± 92.38 | 880.19 ± 133.20 | 802.00 ± 47.29 | 902.67 ± 77.86 | 899.36 ± 102.83 |
| Cd (mg/g Hg) | 1.07; 2.46; 3.39 | 1.63; 1.87; 3.56 | 1.62; 2.43; 3.64 | 1.54; 2.91; 6.04 | 1.78; 4.22; 5.50 | 2.07; 4.49; 11.13 | 1.69; 3.09; 5.15∗,∗∗ | 2.52; 3.59; 7.82∗∗∗,$ | 1.79; 3.83; 5.04$$,$$$ |
Values are shown as mean value ± standard deviation or {1st quartile; median; 3rd quartile}. Data were obtained with the Kruskal–Wallis test with the post hoc Dunn's test. In the case of zinc, data were obtained with the ANOVA. N: number of patients; ∗p < 0.05 compared to control group with G/G genotype; ∗∗p < 0.05 compared to obese group with G/G genotype; ∗∗∗p < 0.05 compared to control group with G/C genotype; $p < 0.05 compared to obese group with G/C genotype; $$p < 0.05 compared to control group with C/C genotype; $$$p < 0.05 compared to obese group with C/C genotype. Bold values represent medians.