Table 1.
Comparison of subtypes according to clinical characteristics
| Characteristic | Controls n = 187 |
Subtype 1 n = 137 |
Subtype 2 n = 124 |
Subtype 3 n = 24 |
Subtype 4 n = 78 |
Subtype 5 n = 56 |
|---|---|---|---|---|---|---|
| Cognitive state, n (%) | ||||||
| Normal cognition | 187 (100) | 51 (37) | 32 (26) | 1 (4)a,b | 15 (19)a | 8 (14)a |
| MCI | 0 | 37 (27) | 28 (23) | 3 (12) | 16 (21) | 19 (34) |
| Dementia | 0 | 49 (36) | 64 (52)a | 20 (83)a,b | 47 (60)a | 29 (52)c |
| Age | 64.01 (11.83) | 64.71 (6.82) | 69.38 (8.35)a,d | 64.46 (8.73)b | 64.28 (8.09)b | 66.16 (8.11)b |
| Men, n (%) | 111 (59) | 62 (45)d | 61 (49) | 10 (42) | 51 (65)a,b | 41 (73%)a,b,c |
| Years of education, mean (s.d.) | 12.4 (3.2) | 12.1 (3.4) | 11.2 (3.2)d | 11.7 (2.9) | 11.9 (3.4) | 11.8 (3.3) |
| ≥1 APOE e4 allele, n (%) | 51 (28) | 88 (68)d | 73 (62)d | 15 (65)d | 47 (64)d | 40 (74%)d |
| AD PRS, mean (s.d.) | 5.6 (0.37) | 5.8 (0.41)d | 5.8 (0.31)d | 6.0 (0.41)d,b | 5.8 (0.46)d | 5.8 (0.34)d |
| CSF total tau, pg ml−1, mean (s.d.) | 199 (88) | 592 (340)d | 765 (447)a,d | 882 (367)a,d | 301 (166)a,b,c,d | 469 (297)a,b,c,d,e |
| CSF p-tau 181, z-score, mean (s.d.) | 0 (0.99) | 3.4 (2.5)d | 5.1 (3.1)a,d | 5.0 (2.5)a,d | 0.6 (1.4)a,b,c,d | 2.1 (2.3)a,b,c,d,e |
| CSF BACE1, pg ml−1, mean (s.d.) | 1931.9 (643.49) | 2203.8 (479.07)d | 2478.49 (687.98)a,d | 2185.33 (573.92)b,d | 1391.36 (323.74)a,b,c,d | 1819.55 (560.55)a,b,c,e |
| CSF Abeta40, pg ml−1, mean (s.d.) | 7135.12 (2134.68) | 7825.31 (1722.1)d | 8519.82 (2264.92)a,d | 6817.46 (1783.25)a,b | 4610.78 (1286.96)a,b,c,d | 5943.02 (1543.58)a,b,c,d,e |
| CSF NRGN, pg ml−1, mean (s.d.) | 317.49 (148.07) | 488.01 (178.95)d | 634.44 (300.5)a,d | 561 (175.88)b,d | 244.09 (97.64)a,b,c,d | 370.91 (166.83)a,b,c,e |
| CSF NEFL, pg ml−1, mean (s.d.) | 360.1 (275.1) | 447.01 (187.34)d | 620.08 (341.41)a,d | 630.12 (293.84)a,d | 453.61 (292.84)b,c,d | 594.16 (371.67)a,d,e |
| CSF VAMP2, pg ml−1, mean (s.d.) | 162.17 (70.43) | 196.32 (61.39)d | 233.44 (79.91)a,d | 188.6 (61.77)b | 100.1 (39.8)a,b,c,d | 141.94 (52.35)a,b,c,d,e |
| Microbleed count on MRI, mean (s.d.) | 0.91 (2.55) | 1.89 (9.80) | 1.16 (3.74) | 1.65 (3.18) | 2.07 (8.02) | 4.40 (17.94)b,d |
aDiffers from subtype 1 with P < 0.05.
bDiffers from subtype 2 with P < 0.05.
cDiffers from subtype 3 with P < 0.05.
dDiffers from controls with P < 0.05.
eDiffers from subtype 4 with P < 0.05.