Figure 5.

Second and third domains of polyphosphate kinase are homologous to phospholipase D. Multiple sequence alignment for representative sequences of polyphosphate kinase (gi|7465499, Group 11) and the phospholipase D family (PDB|1bys [24]) is shown. Highly conserved active site residues are highlighted in black and shown in white bold text. Abbreviations of species names are as follows: Bh Bacillus halodurans, Bj Bradyrhizobium japonicum, Ca Clostridium acetobutylicum, Ch Cytophaga hutchinsonii, Dh Desulfitobacterium hafniense, Ec Escherichia coli, Pa Pseudomonas aeruginosa, Rp Rickettsia prowazekii, St Salmonella typhimurium, Wg Wigglesworthia glossinidia brevipalpis. Locations of predicted (gi|7465499) and observed (PDB|1bys_A) secondary structure elements (E, β-strand; H, α-helix) are marked above the sequences in italics and normal font, respectively.