Table 1.

Classification of kinase activities by family and fold group, part 1.

Group	Family and PFAM/COG members	Kinase Activity (E.C.)	Representative PDB or gi
Group 1: protein S/T-Y kinase/ atypical protein kinase/ lipid kinase/ ATP-grasp 23124 sequences	protein S/T-Y kinase/ atypical protein kinase: COG0478, COG2112, PF00069, PF00454, PF01163, PF01633 22074 sequences	2.7.1.32 Choline kinase (*)	PDB: 1cdk
		2.7.1.37 Protein kinase
		2.7.1.38 Phosphorylase kinase
		2.7.1.39 Homoserine kinase
		2.7.1.67 1-phosphatidylinositol 4-kinase
		2.7.1.72 Streptomycin 6-kinase
		2.7.1.82 Ethanolamine kinase
		2.7.1.87 Streptomycin 3"-kinase
		2.7.1.95 Kanamycin kinase
		2.7.1.100 5-methylthioribose kinase
		2.7.1.103 Viomycin kinase
		2.7.1.109 [Hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase
		2.7.1.112 Protein-tyrosine kinase
		2.7.1.116 [Isocitrate dehydrogenase (NADP+)] kinase
		2.7.1.117 [Myosin light-chain] kinase
		2.7.1.119 Hygromycin-B kinase
		2.7.1.123 Calcium/calmodulin-dependent protein kinase
		2.7.1.125 Rhodopsin kinase
		2.7.1.126 [Beta-adrenergic-receptor] kinase (*)
		2.7.1.129 [Myosin heavy-chain] kinase
		2.7.1.135 [Tau protein] kinase (*)
		2.7.1.136 Macrolide 2'-kinase
		2.7.1.137 1-phosphatidylinositol 3-kinase
		2.7.1.141 [RNA-polymerase]-subunit kinase
		2.7.1.153 Phosphatidylinositol-4,5-bisphosphate 3-kinase
		2.7.1.154 Phosphatidylinositol-4-phosphate 3-kinase
	lipid kinase: PF01504 321 sequences	2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase	PDB: 1bo1
		2.7.1.127 1D-myo-inositol-trisphosphate 3-kinase (*)
		2.7.1.140 Inositol-tetrakisphosphate 5-kinase
		2.7.1.149 1-phosphatidylinositol 5-phosphate 4-kinase
		2.7.1.150 1-phosphatidylinositol 3-phosphate 5-kinase
		2.7.1.151 Inositol-polyphosphate multikinase
		2.7.4.21 Inositol-hexakisphosphate kinase
	ATP-grasp: PF01326 729 sequences	2.7.1.134 Inositol-tetrakisphosphate 1-kinase	PDB: 1dik
		2.7.9.1 Pyruvate, phosphate dikinase
		2.7.9.2 Pyruvate, water dikinase
Group 2: Rossmann-like 17071 sequences	P-loop kinases: COG0645, COG1618, COG1663, COG1936, COG2019, PF00265, PF00406, PF00485, PF00625, PF00693, PF01121, PF01202, PF01583, PF01591, PF01712, PF02223, PF02224, PF02283 7732 sequences	2.7.1.12 Gluconokinase (*)	PDB: 1qf9
		2.7.1.19 Phosphoribulokinase
		2.7.1.21 Thymidine kinase
		2.7.1.22 Ribosylnicotinamide kinase
		2.7.1.24 Dephospho-CoA kinase
		2.7.1.25 Adenylylsulfate kinase
		2.7.1.33 Pantothenate kinase
		2.7.1.37 Protein kinase (bacterial)
		2.7.1.48 Uridine kinase (*)
		2.7.1.71 Shikimate kinase
		2.7.1.74 Deoxycytidine kinase (*)
		2.7.1.76 Deoxyadenosine kinase
		2.7.1.78 Polynucleotide 5'-hydroxyl-kinase (*)
		2.7.1.105 6-phosphofructo-2-kinase
		2.7.1.113 Deoxyguanosine kinase
		2.7.1.130 Tetraacyldisaccharide 4'-kinase
		2.7.1.145 Deoxynucleoside kinase (*)
		2.7.1.156 Adenosylcobinamide kinase
		2.7.4.1 Polyphosphate kinase
		2.7.4.2 Phosphomevalonate kinase
		2.7.4.3 Adenylate kinase
		2.7.4.4 Nucleoside-phosphate kinase
		2.7.4.8 Guanylate kinase
		2.7.4.9 Thymidylate kinase
		2.7.4.10 Nucleoside-triphosphate – adenylate kinase
		2.7.4.13 (Deoxy)nucleoside-phosphate kinase
		2.7.4.14 Cytidylate kinase
		2.7.4.- Uridylate kinase
	phosphoenolpyruvate carboxykinase: COG1493, PF01293, PF00821 815 sequences	2.7.1.37 Protein kinase (HPr kinase/phosphatase)	PDB: 1aq2
		4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP)
		4.1.1.49 Phosphoenolpyruvate carboxykinase (ATP)
	phosphoglycerate kinase: PF00162 1351 sequences	2.7.2.3 Phosphoglycerate kinase	PDB: 13pk
		2.7.2.10 Phosphoglycerate kinase (GTP)
	aspartokinase: PF00696 2171 sequences	2.7.2.2 Carbamate kinase	PDB: 1b7b
		2.7.2.4 Aspartate kinase
		2.7.2.8 Acetylglutamate kinase (*)
		2.7.2.11 Glutamate 5-kinase
		2.7.4.- Uridylate kinase
	phosphofructokinase-like: PF00365, PF00781, PF01219, PF01513 1998 sequences	2.7.1.11 6-phosphofructokinase	PDB: 4pfk
		2.7.1.23 NAD(+) kinase (*)
		2.7.1.56 1-phosphofructokinase
		2.7.1.90 Diphosphate – fructose-6-phosphate 1- phosphotransferase (*)
		2.7.1.91 Sphinganine kinase
		2.7.1.107 Diacylglycerol kinase
		2.7.1.138 Ceramide kinase
	ribokinase-like: PF00294, PF01256, PF02110 2722 sequences	2.7.1.2 Glucokinase	PDB: 1rkd
		2.7.1.3 Ketohexokinase
		2.7.1.4 Fructokinase
		2.7.1.11 6-phosphofructokinase
		2.7.1.15 Ribokinase
		2.7.1.20 Adenosine kinase
		2.7.1.35 Pyridoxal kinase (*)
		2.7.1.45 2-dehydro-3-deoxygluconokinase
		2.7.1.49 Hydroxymethylpyrimidine kinase
		2.7.1.50 Hydroxyethylthiazole kinase
		2.7.1.56 1-phosphofructokinase
		2.7.1.73 Inosine kinase
		2.7.1.92 5-dehydro-2-deoxygluconokinase
		2.7.1.144 Tagatose-6-phosphate kinase
		2.7.1.146 ADP-dependent phosphofructokinase
		2.7.1.147 ADP-dependent glucokinase
		2.7.4.7 Phosphomethylpyrimidine kinase (*)
	thiamin pyrophosphokinase 175 sequences	2.7.6.2 Thiamin pyrophosphokinase	PDB: 1ig0
	glycerate kinase (previously Group 15) 107 sequences	2.7.1.31 Glycerate kinase (*)	PDB: 1to6