Table 2.
Comparison of longitudinality and sampling density variables between concomitant medication and diagnosis domains for the RCT (N = 5 734) and RWD (N = 23 523) patients.
| Concomitant medications | Diagnosis history | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Quartile | RCT | RWD | P value* | Variable | Quartile | RCT | RWD | P value* |
| Pre-index time (Years) | 25% | 3,6 | 2,4 | < 0.001 | Pre-index time (Years) | 25% | 14,9 | 2,7 | < 0.001 |
| Median | 7,7 | 4,9 | Median | 20,3 | 5,2 | ||||
| 75% | 13,7 | 6,5 | 75% | 28,7 | 7,3 | ||||
| Number of events | 25% | 4 | 9 | < 0.001 | Number of events | 25% | 4 | 5 | < 0.001 |
| Median | 6 | 20 | Median | 5 | 13 | ||||
| 75% | 9 | 38 | 75% | 7 | 25 | ||||
| Number of events per year | 25% | 0,5 | 2,9 | < 0.001 | Number of events per year | 25% | 0,2 | 1,7 | < 0.001 |
| Median | 0,8 | 5,4 | Median | 0,3 | 3,3 | ||||
| 75% | 1,6 | 10,0 | 75% | 0,4 | 7,6 | ||||
| Number of unique medications | 25% | 10 | 14 | < 0.001 | Number of unique diagnoses | 25% | 5 | 5 | < 0.001 |
| Median | 14 | 23 | Median | 7 | 9 | ||||
| 75% | 19 | 34 | 75% | 9 | 15 | ||||
| Interval between events (Days) | 25% | 113,3 | 3,0 | < 0.001 | Interval between events (Days) | 25% | 464,6 | 13,0 | < 0.001 |
| Median | 288,0 | 13,5 | Median | 914,0 | 31,0 | ||||
| 75% | 576,5 | 41,0 | 75% | 1826,0 | 89,0 | ||||
*Presented P values were adjusted with Bonferroni correction to address the issue of multiple comparisons.