Table 3.
Demographic, clinical, and CSF characteristics stratified by Imax Tertile groups.
| Imax | Lowest tertile (lowest Imax) | Mid-tertile | Highest Tertile (highest Imax) | p value |
|---|---|---|---|---|
| Male sex % | 67 | 72 | 63 | 0.571 |
| Age, years | 63 ± 9 | 64 ± 11 | 66 ± 8 | 0.097 |
| Age at onset, years | 57 ± 9 | 57 ± 10 | 59 ± 8 | 0.347 |
| Disease duration, years | 6 ± 4 | 7 ± 5 | 7 ± 5 | 0.243 |
| H&Y | 1.9 ± 0.6 | 2.2 ± 0.6 | 2.2 ± 0.7* | 0.038 |
| H&Y ≥ 2.5% | 9 | 20 | 22 | 0.091 |
| UPDRS-III | 24 ± 10 | 26 ± 12 | 27 ± 11 | 0.176 |
| Montreal Cognitive Assessment | 27 ± 3 | 24 ± 5°° | 24 ± 4** | ≤0.001 |
| Cognitive impairment | ||||
| At baseline % | 19 | 48 | 38 | 0.002 |
| New during study % | 17 | 21 | 39 | 0.047 |
| Cognitive impairment anytime % | 33 | 60 | 62 | ≤0.001 |
| BDI-II | 9 ± 7 | 10 ± 7 | 8 ± 7 | 0.535 |
| LEDD | 486 ± 406 | 597 ± 353 | 451 ± 321 | 0.060 |
| Amyloidβ1–42 [pg/ml] | 756 ± 244 | 703 ± 271 | 685 ± 270 | 0.264 |
| Total-Tau [pg/ml] | 251 ± 160 | 251 ± 136 | 218 ± 87 | 0.259 |
| Phospho181-Tau [pg/ml] | 41 ± 15 | 42 ± 17 | 38 ± 13 | 0.355 |
| AD Profile % | 1.5 | 0 | 0 | 0.377 |
| Neurofilament light chain [pg/ml] | 948 ± 1282 | 937 ± 508 | 858 ± 455 | 0.803 |
| Total α-synuclein [pg/ml] | 601 ± 271 | 571 ± 245 | 524 ± 254 | 0.221 |
| Patients with GBA mutation | 34% | 50% | 46% | 0.165 |
| Patients with LRKK2 mutation | 0% | 5% | 6% | 0.148 |
| Patients with PRKN mutation | 10% | 2% | 5% | 0.164 |
BDI-II Becks depression Inventory version II, H&Y Hoehn and Yahr, LEDD Levodopa Equivalent Daily Dose, UPDRS-III Unified Parkinson Disease Rating Scale part III.
Data are presented as mean and standard deviation. AD Alzheimer’s Disease CSF profile defined by the National Institute on Aging (NIA)-Alzheimer’s Association (AA) Research Framework.
Post-hoc Bonferroni subgroup comparison for continuous data lowest vs. mid-tertile with levels of significance: °p < 0.05; °°p < 0.01; °°°p ≤ 0.001.
Post-hoc Bonferroni subgroup comparison for continuous data lowest vs. highest Tertile with levels of significance: *p < 0.05; **p < 0.01; ***p ≤ 0.001.