NMR structure and schematic illustration of GQ topologies. (A-B) Hybrid-1; (C-D) Parallel; (E-F) Antiparallel; (G-H) Hybrid-2 topologies. A schematic of a G-Tetrad with four guanines at the corners and a monovalent cation in the middle is shown in the center of the figure. The NMR structures in A, C, E, and F were created in Chimera software using PDB ID 2JSM, 1KF1, 2KF8 and 2JSL, respectively.