Table 2. Overall and Subgroup Cox Regression Analysis Output.
| Population | All-cause | Cardiovascular disease | ||
|---|---|---|---|---|
| Deaths, No. | HR (95% CI) | Deaths, No. | HR (95% CI) | |
| All participants | ||||
| Mostly sitting | 15 045 | 1.16 (1.11-1.20) | 3234 | 1.34 (1.22-1.46) |
| Alternating sitting and nonsitting | 7257 | 1.01 (0.97-1.05) | 1407 | 1.11 (1.00-1.22) |
| Mostly nonsitting | 3955 | 1 [Reference] | 730 | 1 [Reference] |
| Men | ||||
| Mostly sitting | 8077 | 1.13 (1.08-1.19) | 1784 | 1.32 (1.19-1.47) |
| Alternating sitting and nonsitting | 3658 | 1.01 (0.96-1.06) | 703 | 1.09 (0.97-1.22) |
| Mostly nonsitting | 3084 | 1 [Reference] | 567 | 1 [Reference] |
| Women | ||||
| Mostly sitting | 6968 | 1.21 (1.12-1.31) | 1450 | 1.29 (1.07-1.55) |
| Alternating sitting and nonsitting | 3599 | 1.03 (0.95-1.12) | 704 | 1.09 (0.90-1.31) |
| Mostly nonsitting | 871 | 1 [Reference] | 163 | 1 [Reference] |
| Age <60 y | ||||
| Mostly sitting | 5563 | 1.06 (1.00-1.12) | 925 | 1.33 (1.14-1.54) |
| Alternating sitting and nonsitting | 3665 | 0.99 (0.93-1.05) | 578 | 1.18 (1.01-1.38) |
| Mostly nonsitting | 1962 | 1 [Reference] | 305 | 1 [Reference] |
| Age ≥60 y | ||||
| Mostly sitting | 9482 | 1.23 (1.16-1.29) | 2309 | 1.32 (1.17-1.48) |
| Alternating sitting and nonsitting | 3592 | 1.02 (0.96-1.08) | 829 | 1.06 (0.93-1.20) |
| Mostly nonsitting | 1993 | 1 [Reference] | 425 | 1 [Reference] |
| Smokers | ||||
| Mostly sitting | 5561 | 1.14 (1.08-1.20) | 1199 | 1.27 (1.12-1.43) |
| Alternating sitting and nonsitting | 2671 | 1.01 (0.95-1.07) | 497 | 1.05 (0.92-1.20) |
| Mostly nonsitting | 2190 | 1 [Reference] | 398 | 1 [Reference] |
| Never smokers | ||||
| Mostly sitting | 8737 | 1.17 (1.11-1.24) | 1875 | 1.40 (1.23-1.61) |
| Alternating sitting and nonsitting | 4180 | 1.02 (0.96-1.08) | 836 | 1.17 (1.01-1.35) |
| Mostly nonsitting | 1560 | 1 [Reference] | 281 | 1 [Reference] |
| Body mass index ≥25a | ||||
| Mostly sitting | 5835 | 1.13 (1.06-1.21) | 1433 | 1.42 (1.23-1.65) |
| Alternating sitting and nonsitting | 2805 | 0.98 (0.91-1.05) | 605 | 1.15 (0.98-1.34) |
| Mostly nonsitting | 1350 | 1 [Reference] | 271 | 1 [Reference] |
| Body mass index ≥30a | ||||
| Mostly sitting | 995 | 1.20 (1.01-1.42) | 265 | 1.72 (1.17-2.54) |
| Alternating sitting and nonsitting | 436 | 0.96 (0.80-1.16) | 103 | 1.31 (0.87-1.98) |
| Mostly nonsitting | 184 | 1 [Reference] | 39 | 1 [Reference] |
| With hypertension | ||||
| Mostly sitting | 6627 | 1.08 (1.02-1.14) | 954 | 1.27 (1.09-1.47) |
| Alternating sitting and nonsitting | 3658 | 0.96 (0.91-1.02) | 471 | 1.06 (0.90-1.25) |
| Mostly nonsitting | 2206 | 1 [Reference] | 295 | 1 [Reference] |
| Without hypertension | ||||
| Mostly sitting | 8418 | 1.21 (1.14-1.28) | 2280 | 1.28 (1.03-1.58) |
| Alternating sitting and nonsitting | 3599 | 1.01 (0.95-1.08) | 936 | 0.96 (0.76-1.22) |
| Mostly nonsitting | 1749 | 1 [Reference] | 435 | 1 [Reference] |
| Without diabetes | ||||
| Mostly sitting | 11 514 | 1.12 (1.07-1.17) | 2449 | 1.33 (1.20-1.47) |
| Alternating sitting and nonsitting | 5959 | 1.00 (0.95-1.04) | 1158 | 1.13 (1.01-1.26) |
| Mostly nonsitting | 3347 | 1 [Reference] | 610 | 1 [Reference] |
| With diabetes | ||||
| Mostly sitting | 3531 | 1.20 (1.09-1.32) | 785 | 1.28 (1.03-1.58) |
| Alternating sitting and nonsitting | 1298 | 0.97 (0.88-1.08) | 249 | 0.96 (0.76-1.22) |
| Mostly nonsitting | 608 | 1 [Reference] | 120 | 1 [Reference] |
Abbreviation: HR, hazard ratio.
a
Body mass index is calculated as weight in kilograms divided by height in meters squared.