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Protection studies in the chinchilla intrabulla challenge model of otitis media. Chinchillas (1 to 2 years old) were immunized three times (i.m.) with 30 μg of antigen adsorbed to alum. Two weeks after the last injection, animals were challenged with live NTHI strain 12 (50 to 350 CFU) (A and B) or LCDC2 (200 CFU) (C) through the epitympanic bulla. Middle ear fluid was collected 4 days postchallenge. Each data point represents the bacteria recovered from a single chinchilla.
