Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 20;31:10. doi: 10.1186/s12929-023-00991-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — PTX3 expression is positively correlated with stromal and fibroblast signatures in colon cancer. A total of 287 colon adenocarcinoma samples represented in the TCGA dataset were divided into the PTX3^high (n = 143) and PTX3^low (n = 144) groups by the median cutoff value. A KEGG pathways related to cellular processes were selected for gene set enrichment analysis (GSEA), and the enriched signaling pathways (blue, inflammation-related signaling; and black, and stromal activation-related signaling) in PTX3^high tumors are shown. The threshold criteria were p value of < 0.05 and FDR < 0.25. B GSEA of inflammatory response signature in the PTX3^high (n = 143) and PTX3^low (n = 144) groups. The threshold criteria were NES > 1.5, p value of < 0.05, and FDR < 0.25. C The stromal scores of 191 colon adenocarcinoma samples from the TCGA dataset were extracted via the ESTIMATE web tool and used for Pearson correlation analysis with PTX3 expression levels (log2). D, E Fibroblast scores in 283 colorectal tumor samples from the TCGA dataset were extracted from the xCell database. The samples were divided into the PTX3^high (n = 142) and PTX3^low (n = 141) expression groups or the fibroblast^high (n = 142) and fibroblast^low (n = 141) score groups by the median cutoff value. F, G The survival index of 203 colorectal adenocarcinoma patients was obtained via the SurvExpress web-tool. The samples were divided into the fibroblast^high (n = 114) and fibroblast^low (n = 89) group by the best cutoff value, and each of these groups was subdivided into a PTX3^high group and a PTX3^low group by the median cutoff value. H PTX3 expression and I fibroblast scores in different stages in the TCGA COAD dataset are shown. Spearman correlation analysis of PTX3 expression and the fibroblast score in stage I (J), stage II (K), stage III (L), and stage IV (M) tumors. p values were calculated by two-tailed unpaired Student's t test, one-way ANOVA, two-sided log-rank test, HR hazard ratio, or CI confidence interval. ns represents nonsignificant difference. ***represents a p value of < 0.001. Values on the plots are presented as the means ± SEMs