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. 2024 Jan 19;22:35. doi: 10.1186/s12951-024-02295-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — si-circNUP50 and platinum co-delivery using nanosystems to overcome platinum resistance in an OC tumour model. A Structure of the Psc@DPP co-delivery nanosystem. B and C The particle size of Psc@DPP is 150 nm, and the zeta potential of Psc@DPP is + 15 mV. D The transmission electron microscopy image of Psc@DPP. E Fluorescence signals corresponding to platinumCy3 and si-circNUP50Cy5 on Psc@DPP were statistically analysed using Pearson’s correlation test. F The Pearson’s correlation coefficient of platinumCy3 and si-circNUP50Cy5 on Psc@DPP was 0.86. G After co-incubating Psc@DPP with ovarian tumour cells for 4 h, Psc@DPPs delivered platinumCy3 and si-circNUP50Cy5 into OC cells. H The serum stability of Psc@DPP within 24 h and the storage stability of the nanoparticles within 7 days was good. I and J The fluorescence intensity was significantly lower in the Psc@DPP group compared than in the PBS and platinum groups, whereas there was no significant change in fluorescence intensity in the platinum + si-circNUP50 group. K Haematoxylin and eosin staining of OC tissues revealed decreased tumour area in the Psc@DPP group when compared with that in the other groups