Table 4.
Significant component genes from verbal declarative memory-associated pathways
| Gene | GeneID | Meta discovery | Meta replication | Meta joint | ||||
|---|---|---|---|---|---|---|---|---|
| PAR-dr (M/Gene_p) | WL-dr (M/Gene_p) | PAR-dr (M/Gene_p) | WL-dr (M/Gene_p) | PAR-dr (M/Gene_p) | WL-dr (M/Gene_p) | |||
| MHC Class 1 | HLA-Aa | 3105 | 5/1.54E − 05 | 10/2.32E − 10 | 1/0.34 | 1/0.34 | 6/8.09E − 05 | 11/3.76E − 09 |
| HLA-Ba | 3106 | 6/4.01E − 07 | 13/1.17E − 15 | 1/0.34 | 0/1.00 | 7/5.98E − 6 | 13/8.69E − 12 | |
| HLA-Ca | 3107 | 8/3.91E − 11 | 14/8.73E − 18 | 0/1.00 | 0/1.00 | 8/3.50E − 7 | 14/3.25E − 13 | |
| HLA-Ea | 3133 | 3/0.006 | 9/7.42E − 09 | 0/1.00 | 0/1.00 | 3/0.043 | 9/8.39E − 07 | |
| HLA-Fa | 3134 | 3/0.006 | 9/7.42E − 09 | 2/0.057 | 0/1.00 | 5/8.57E − 04 | 9/8.39E − 07 | |
| HLA-Ga | 3135 | 6/4.01E − 07 | 13/1.17E − 15 | 0/1.00 | 0/1.00 | 6/8.09E − 05 | 13/8.69E − 12 | |
| HLA-H | 3136 | 3/0.006 | 12/9.64E − 14 | 2/0.057 | 1/0.34 | 5/8.57E − 04 | 13/8.69E − 12 | |
| MHC Class II | HLA-DMAa | 3108 | 6/4.01E − 07 | 11/5.53E − 12 | 0/1.00 | 1/0.34 | 6/8.09E − 05 | 12/1.96E − 10 |
| HLA-DMBa | 3109 | 7/5.98E − 09 | 12/9.64E − 14 | 1/0.34 | 0/1.00 | 8/3.50E − 7 | 12/1.96E − 10 | |
| HLA-DPA1a | 3113 | 5/1.54E − 05 | 11/5.53E − 12 | 0/1.00 | 1/0.34 | 5/8.57E − 04 | 12/1.96E − 10 | |
| HLA-DPB1a | 3115 | 5/1.54E − 05 | 11/5.53E − 12 | 0/1.00 | 0/1.00 | 5/8.57E − 04 | 11/3.76E − 09 | |
| HLA-DPB2 | 3116 | 7/5.98E − 09 | 11/5.53E − 12 | 0/1.00 | 0/1.00 | 7/5.98E − 06 | 11/3.76E − 09 | |
| HLA-DQA2 | 3118 | 7/5.98E − 09 | 10/2.32E − 10 | 0/1.00 | 0/1.00 | 7/5.98E − 06 | 10/6.11E − 08 | |
| HLA-DQB2 | 3120 | 7/5.98E − 09 | 11/5.53E − 12 | 0/1.00 | 0/1.00 | 7/5.98E − 06 | 11/3.76E − 09 | |
| HLA-DRAa | 3122 | 5/1.54E − 05 | 13/1.17E − 15 | 0/1.00 | 3/0.006 | 5/8.57E − 04 | 16/2.67E − 16 | |
This table shows significant gene-based tests results for the component genes from the six memory-associated pathways. The binomial test was used to meta-analyze the gene associations (U-scores) across cohorts. Gene is the gene name or symbol; GeneID is the NCBI gene identifier; PAR-dr and WL-dr represent the results of the gene-based tests for the paragraph and word list delayed recall traits, respectively; M is the number of cohorts in which the gene had a U-score ≤ 0.05; Gene_p is the meta-analysis p-value (significant for values ≤ 1E − 06)
aIndicates a gene that is a component of all six memory-associated pathways