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. 2005 Apr 14;33(7):2192–2203. doi: 10.1093/nar/gki514

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© The Author 2005. Published by Oxford University Press. All rights reserved

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(a) Long-term proliferation curve of A549 or A549::Bcl-2 cells in the absence (open and closed circles, respectively) or presence of 12459 (0.5 μM) (open and closed triangles, respectively). A cell growth plateau appears at day 8 and cells enter senescence at day 20 for both 12459-treated cell lines at a population doubling equal to 5. (b) Expression of SA β-galactosidase activity in untreated A549 or A549::Bcl-2 cells (A549, A549Bcl-2) or in cells treated with 0.5 μM 12459 (+ 12459) for 20 days.