Table 3.
Associations Between Log GFAP and Baseline Cognitive Function and Cognitive Decline, Stratified by Depressive Symptom Status
| Outcome | Global Cognition | Episodic Memory | Perceptual Speed | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low CES-D | High CES-D | Low CES-D | High CES-D | Low CES-D | High CES-D | |||||||||||||
| Subjects | 919 | 240 | 914 | 236 | 897 | 224 | ||||||||||||
| Total observations | 2 825 | 675 | 2792 | 660 | 2743 | 622 | ||||||||||||
| β | SE | p Value | β | SE | p Value | β | SE | p Value | β | SE | p Value | β | SE | p Value | β | SE | p Value | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Log GFAP | −0.183 | 0.086 | .033 | −0.729 | 0.195 | .000 | −0.134 | 0.114 | .238 | −0.877 | 0.241 | .000 | −0.289 | 0.113 | .010 | −0.305 | 0.228 | .182 |
| Log GFAP × time | −0.069 | 0.017 | .000 | −0.097 | 0.040 | .015 | −0.072 | 0.021 | .001 | −0.066 | 0.049 | .174 | −0.043 | 0.018 | .014 | −0.030 | 0.043 | .481 |
Notes: Models were adjusted for age, race, sex, education, BMI, current and former smoking, alcohol use, chronic medical conditions and each of their interactions with time for the longitudinal models. BMI = body mass index; CES-D = Center for Epidemiologic Studies—Depression; GFAP = glial fibrillary acid protein; SE = standard error.