Table 2.
The Coefficient for Each Tertile of the Selected Biomarkers (N = 3 197)
| Women (N = 1 955) | Men (N = 1 242) | |||||
|---|---|---|---|---|---|---|
| Range | Coefficient | Point* | Range | Coefficient | Point | |
| NT-proBNP, pg/mL | ||||||
| 1st tertile | ≤94 | 0 | 0 | ≤74 | 0.00 | 0 |
| 2nd tertile | >94, ≤199 | 0.47 | 2 | >74, ≤201 | 0.19 | 1 |
| 3rd tertile | >199 | 0.82 | 3 | >201 | 0.84 | 3 |
| IGF, µg/L | ||||||
| 1st tertile | ≤77 | (not included in BI) | ≤91 | 0.00 | 0 | |
| 2nd tertile | >77, ≤101 | >91, ≤116 | 0.10 | 0 | ||
| 3rd tertile | >101 | >116 | 0.38 | 1 | ||
| IL-6, pg/mL | ||||||
| 1st tertile | ≤2.0 | 0 | 0 | ≤2.3 | 0.00 | 0 |
| 2nd tertile | >2.0, ≤3.3 | 0.16 | 1 | >2.3, ≤3.6 | 0.18 | 1 |
| 3rd tertile | >3.3 | 0.56 | 2 | >3.6 | 0.63 | 2 |
| Cystatin-C, mg/L | ||||||
| 1st tertile | ≤0.94 | 0.13 | 1 | ≤0.99 | (not included in BI) | |
| 2nd tertile | >0.94, ≤1.11 | 0.00 | 0 | >0.99, ≤1.17 | ||
| 3rd tertile | >1.11 | 0.30 | 1 | >1.17 | ||
| C-reaction protein, mg/L | ||||||
| 1st tertile | ≤1.6 | (not included in BI) | ≤1.4 | (not included in BI) | ||
| 2nd tertile | >1.6, ≤4.7 | >1.4, ≤3.5 | ||||
| 3rd tertile | >4.7 | >3.5 | ||||
| TNFsR1, pg/mL | ||||||
| 1st tertile | ≤1 212 | (not included in BI) | ≤1 259 | 0.03 | 0 | |
| 2nd tertile | >1 212, ≤1 522 | >1 259, ≤1 595 | 0.00 | 0 | ||
| 3rd tertile | >1 522 | >1 595 | 0.41 | 1 | ||
| Insulin, mIU/L | ||||||
| 1st tertile | ≤8 | (not included in BI) | ≤8 | (not included in BI) | ||
| 2nd tertile | >8, ≤12 | >8, ≤12 | ||||
| 3rd tertile | >12 | >12 | ||||
| Fasting glucose, mg/dL | ||||||
| 1st tertile | ≤93 | 0.14 | 1 | ≤95 | 0.00 | 0 |
| 2nd tertile | >93, ≤102 | 0.00 | 0 | >95, ≤107 | 0.28 | 1 |
| 3rd tertile† | >102 | 0.56 | 2 | >107 | 0.43 | 2 |
Notes: The Cox model employed an adjustment procedure that included all biomarkers and age. BI = biomarker index.
*The points are calculated as the ratio of the coefficient of the biomarker to the product of 3 and the coefficient of age in each gender. All points consolidated into the final BI.
†Subjects diagnosed with diabetes were allocated to the third category of fasting glucose levels.