Table 5.

Hazard Ratios of Composite Outcome for Biomarker Index Score or Individual Biomarkers (N = 3 197)

	Women (N = 1 955)		Men (N = 1 242)
	HR (95% CI) for BI Score (per SD)	AUC	HR (95% CI) for BI Score (per SD)	AUC
BI score*	1.45 (1.28, 1.59)	0.64 (0.62, 0.67)	1.52 (1.39, 1.66)	0.68 (0.65, 0.70)

Individual biomarker†	HR (95% CI) for each biomarker (per SD)	AUC	HR (95% CI) for each biomarker (per SD)	AUC
NT-proBNP	1.48 (1.35, 1.63)	0.59 (0.57, 0.63)	1.63 (1.46, 1.82)	0.63 (0.61, 0.66)
IL-6	1.28 (1.16, 1.40)	0.55 (0.53, 0.59)	1.42 (1.28, 1.57)	0.59 (0.57, 0.63)
Cystatin-C	1.39 (1.27, 1.52)	0.58 (0.55, 0.61)	(Cystatin-C not included in men’s BI)
Fasting glucose	1.15 (1.05, 1.26)	0.53 (0.50, 0.56)	1.22 (1.11, 1.35)	0.58 (0.53, 0.64)
IGF	(IGF not included in women’s BI)		0.97 (0.87, 1.07)	0.48 (0.46, 0.51)
TNFsR1	(TNFsR1 not included in women’s BI)		1.42 (1.30, 1.58)	0.58 (0.56, 0.62)

Notes: AUC = area under receiver-operating characteristic curve; BI = biomarker index; CI = confidence interval; HR = hazard ratio; IGF = insulin-like growth factor; IL-6 = interleukin-6; NT-proBNP = amino-terminal pro-B-type natriuretic peptide; SD = standard deviation; TNFsR1 = tumor necrosis factor alpha soluble receptor 1.

^*Model comprised of standardized BI, standardized age, and race.

^†Models comprised of standardized single biomarker level, standardized age, and race. Standard deviations for each biomarker given in Table 1.