Table 3.

Sensitivity and subgroup analyses of the cost-effectiveness of pre-operative compared to post-operative RT

Scenario	Cost difference	Effect difference	ICER
Base case	6859	− 13.9	Dominated
Sensitivity analysis
Outpatient costs adjusted + 1SD	6714	− 13.9	Dominated
Outpatient costs adjusted -1SD	7002	− 13.9	Dominated
Inpatient costs adjusted + 1SD	6897	− 13.9	Dominated
Inpatient costs adjusted -1SD	6819	− 13.9	Dominated
Indirect costs adjusted + 1SD	2962	− 13.9	Dominated
Indirect costs adjusted –1SD	10,754	− 13.9	Dominated
Effect-adjusted + 1SD	6859	− 9.8	Dominated
Effect-adjusted –1SD	6859	− 18.0	Dominated
Subgroup analyses
Age
23–65 (47/51)	2842	− 12.9	Dominated
66–84 (51/60)	8532	− 14.9	Dominated
Gender
Female (32/43)	3232	− 10.1	Dominated
Male (66/68)	9509	− 14.5	Dominated
Clinical stage
I/II (49/56)	10,746	− 10.6	Dominated
III/IVA (49/55)	2884	− 17.2	Dominated
Subsite
Tongue/floor of mouth (66/79)	8348	− 14.2	Dominated
Gingiva and other oral subsites (32/32)	5889	− 13.9	Dominated

All costs are expressed in PPP-adjusted Euro (€) for 2019 and effects in percentage points. Population size for pre- versus post-op RT in paratheses

PPP purchasing power parity, RT radiotherapy, SD standard deviation