Table1.
CD133 regulation in tumor cells by soluble factors in the microenvironment
| Cancer | Tumor-associated cells1 | Secreted factors | Signaling induced in tumor cells | Reference |
|---|---|---|---|---|
| HCC | Stellate cells (CAFs transformation) | IL6/HGF | ND | [167, 168] |
| HGF | ND | [169] | ||
| SCUBE1 | Shh/GLI-1 | [170] | ||
| Ectopic | IL6 | STAT3/NFkB | [171] | |
| Ectopic | LPS | NFkB/HIF-1α | [172] | |
| HBx-infected hepatoma cells | HUEVECs | TGFβ | TGFβ signaling | [173] |
| Thyroid cancer | M2-like macrophages | Wnt ligands? (ND) | β-catenin | [174] |
| Neurons | Acetylcholine | M3R/p-Src/CD133/Akt | [175] | |
| Glioma | T Regs | TGF beta | NFKB/IL6/STAT | [176] |
| Ectopic | Leptin | ObR/STAT/Notch | [177] | |
| Medulloblastoma | Astrocytes | DN | DN | [178] |
| Colo-rectal cancer (CRC) | Ectopic | IL25 | AMPK/SHH/GLI1 | [179] |
| Myofibroblasts | IL6, IL8 | STAT3/Notch | [180] | |
| Jurkat cells | TNFβ | NFkB | [181] | |
| MSCs (placenta) | IL8 | CXCR2/ERK | [182] | |
| CD206 + macrophages | Cytokines | ND | [183] | |
| Tumor associated macrophages | TAM-conditioned medium | STAT3 | [184] | |
| Ovarian cancer | Ectopic/CD68 + macrophages | IL17 | NFkB | [185] |
| M2-like macrophages | IL8 | ND | [186] | |
| Oral Cancer | M1-like macrophages | TNFα, IL6, IL1β | ND | [187] |
| CAFs | CXCL2/IL6 | ND | [188] | |
| Pancreatic cancer | Stellate cells (CAFs transformation) | IL6 | STAT3 | [189] |
| Adypocites | Conditioned medium | ND | [190] | |
| Lung cancer | BM-MSC | IL6 | IL6R/STAT | [191] |
| Esophageal squamous carcinoma | Ectopic | IL23 | STAT3 | [192] |
1Soluble factors secreted by tumor-associated cells are referenced; in various studies its effect was evaluated by ectopic expression to resemble tumor-associated cells secretion. ND: no detected or not evaluated