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Non-compartmental pharmacokinetic analysis of HPMA-CHP, HPMA-SCHP, and CHP at the tumor, showing area under the curve (AUC), maximum concentration (Cmax), time to maximum concentration (tmax), and half-life (t1/2), determined using fluorescent signal in radiant efficiency (rad eff) units.
| HPMA-CHP | HPMA-SCHP | CHP | |
|---|---|---|---|
| AUC (rad eff × hr) | 1.68 × 1013 | 9.09 × 1012 | 1.26 × 1013 |
| Cmax (rad eff) | 1.74 × 1011 | 8.80 × 1010 | 1.97 × 1011 |
| tmax (hr) | 24 | 24 | 6 |
| t1/2 (hr) | 74.2 | 66.5 | 59.8 |
