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. 2024 Jan 20;14:1794. doi: 10.1038/s41598-024-51920-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Manhattan plot (− log p vs (a) m/z or (b) retention time) of metabolites determined by MWAS to be associated with LS7 (as a continuous variable) after adjusting for age and sex. 8211 metabolic features underwent MWAS analysis. 301 metabolic features were differentially expressed at FDR < 0.2; 232 metabolic features colored red were lower with higher LS7 and 69 metabolic features colored blue were higher with higher LS7. Retention time is expressed in seconds.