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. 2024 Jan 20;9:17. doi: 10.1038/s41541-024-00806-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Somatic hypermutation in S-specific MBCs 2 weeks after boost 1 and 2. The number below represents the number of sequences included in the analysis at each timepoint. B Somatic hypermutation in Spike+ RBD+ and Spike+ RBD- MBCs 2 weeks after boost 1 and 2. The number below represents the number of sequences included in the analysis at each timepoint. C Avidity index of Spike-binding IgG plasma antibodies at different timepoints (n = 6), determined by chaotropic wash ELISA with 2 M NaSCN as the chaotropic reagent. D Correlation between average mutational load in circulating Spike-specific memory B cells and polyclonal serum antibody avidity (n = 6). Dashed line in the violin plots represents the median and dotted lines the quartiles (A, B). Data points are presented as mean ± SEM (C). Statistical analysis was performed using Kruskal-Wallis test (A), Kruskal-Wallis test with Dunn’s post hoc correction (B) or Spearman correlation (D).