Table 2.

Summary of model performance corrected for optimism by LOOCV including naive confidence intervals.

	Pre-treatment	On-treatment	Post-treatment
	AUC (95% CI)	AUC (95% CI)	AUC (95% CI)
Clinical-radiological	0.76 (0.62–0.88)	0.83 (0.71–0.93)	0.82 (0.71–0.92)
Liquid biopsies	NA	0.51 (0.34–0.67)	0.76 (0.63–0.88)
MRI features	NA	0.66 (0.51–0.81)	0.69 (0.53–0.81)
Clinical-radiological + liquid biopsies	0.77 (0.64–0.88)	0.82 (0.71–0.92)	0.86 (0.76–0.94)
Clinical-radiological + MRI features	0.77 (0.64–0.88)	0.82 (0.70–0.92)	0.83 (0.70–0.93)
Liquid biopsies + MRI features	NA	0.64 (0.47–0.78)	0.76 (0.64–0.88)
Clinical-radiological + liquid biopsies + MRI features	0.76 (0.63–0.88)	0.81 (0.70–0.91)	0.86 (0.75–0.94)
Only clinical	0.76 (0.62–0.87)	0.76 (0.62–0.87)	0.76 (0.62–0.87)
Only clinical + liquid biopsies	0.76 (0.63–0.87)	0.78 (0.65–0.88)	0.85 (0.74–0.94)
Only clinical + MRI features	0.76 (0.63–0.87)	0.82 (0.71–0.91)	0.84 (0.72–0.93)
Only clinical + MRI features + liquid biopsies	0.76 (0.63–0.87)	0.81 (0.70–0.91)	0.85 (0.74–0.93)

CI confidence interval, AUC area under the receiver operating characteristic curve to discriminate between pCR (RCB 0) and non-pCR, NA not applicable (no predictors remained in the model).