Table 1.
SAR Exploration of compounds 1-6
Compound | Structure | % Inhibition at 10 μM (SD) | IC50 (nM) |
---|---|---|---|
1 | ![]() |
2 | ND |
2 | ![]() |
88 ± 2.60 | 232 |
3 | ![]() |
-1 | ND |
4 | ![]() |
2 | ND |
5 | ![]() |
8 | ND |
6 | ![]() |
95 ± 0.31 | 119 |
SD Standard Deviation, ND Not determined.
SAR Exploration of compounds 1-6
Compound | Structure | % Inhibition at 10 μM (SD) | IC50 (nM) |
---|---|---|---|
1 | ![]() |
2 | ND |
2 | ![]() |
88 ± 2.60 | 232 |
3 | ![]() |
-1 | ND |
4 | ![]() |
2 | ND |
5 | ![]() |
8 | ND |
6 | ![]() |
95 ± 0.31 | 119 |
SD Standard Deviation, ND Not determined.