Table 6.

Pharmacokinetic parameters of compound 11c

Tissue	Cmax (ng equiv./g)	Tmax (h)	T1/2 (h)	AUC0-t (ng equiv./g)	AUCinf (ng equiv./g)	Tissue: plasma**
Plasma	225	0.5	NC	783	NC	1.00
Whole Blood	158	0.5	NC	589	NC	0.75
Adrenal gland	1510	6	NC	7210	NC	9.21
Brain	BQL	NC	NC	NR	NC	NA
Heart	369	6	NC	1800	NC	2.30
Kidney	1840	6	NC	7860	NC	10.0
Large Intestine	9800	6	NC	127000	NC	162
Liver	2920	6	NC	15400	NC	19.7
Lung	941	6	NC	4290	NC	5.48
Pancreas	4330	6	NC	15400	NC	19.7
Small Intestine	45000	0.25	NC	16600	NC	21.2
Spleen	2290	6	NC	9520	NC	12.2
Stomach	3240	0.25	NC	5130	NC	6.55

Equivalents in Plasma and Tissue of Male Sprague Dawley Rats following an Oral Dose of [¹⁴C]-11c at 5 mg/kg. (NC= Not calculated due to insufficient terminal elimination phase, NA Not applicable, NR Not reportable due to <3 consecutive quantifiable concentrations, BQL Below the lower limit of quantitation 148 ng equiv./g, **Tissue: plasma ratio based on AUC0-t).